Oral hygiene compositions and methods of use

ABSTRACT

Disclosed herein are oral hygiene compositions, dental flossing material, and methods of treatment using the same. In some embodiments, the oral hygiene composition comprises a remineralization agent, an anti-inflammatory agent, a prebiotic agent, and an alkalizing agent.

INCORPORATION BY REFERENCE TO ANY PRIORITY APPLICATIONS

Any and all applications for which a foreign or domestic priority claimis identified in the Application Data Sheet as filed with the presentapplication are hereby incorporated by reference under 37 CFR 1.57, andRules 4.18 and 20.6, including U.S. Provisional Application Nos.63/191225, filed May 20, 2021 and 63/311,383, filed Feb. 17, 2022.

BACKGROUND

Conventional oral care products contain fluoride as the primary activeingredient to protect enamel against cavities. However, overexposure tofluoride may cause detrimental effects, such as fluorosis andneurological toxicities. In addition, although oral care products mayutilize hydroxyapatite in an attempt to strengthen teeth enamel, teethhave living structures on the inside and greater penetration ofhydroxyapatite would be beneficial to help teeth remineralize from theoutside and inside. Furthermore, conventional oral care products,including products that do and do not utilize fluoride, may containingredients that negatively affect oral microbiomes.

SUMMARY

For purposes of summarizing the disclosure and the advantages achievedover the prior art, certain objects and advantages of the disclosure aredescribed herein. Not all such objects or advantages may be achieved inany particular embodiment. Thus, for example, those skilled in the artwill recognize that the invention may be embodied or carried out in amanner that achieves or optimizes one advantage or group of advantagesas taught herein without necessarily achieving other objects oradvantages as may be taught or suggested herein.

All of these embodiments are intended to be within the scope of theinvention herein disclosed. These and other embodiments will becomereadily apparent to those skilled in the art from the following detaileddescription of the preferred embodiments having reference to theattached figures, the invention not being limited to any particularpreferred embodiment(s) disclosed.

In one aspect, an oral hygiene composition is described. The oralhygiene composition includes at least the following ingredients: aremineralization agent, an anti-inflammatory agent, a prebiotic agent,and an alkalizing agent.

In some embodiments, the remineralization agent comprises a compoundselected from the group consisting of hydroxyapatite, vitamin D3,vitamin K2, calcium carbonate, dicalcium phosphate, fluoride, andcombinations thereof. In some embodiments, the remineralization agentcomprises hydroxyapatite, vitamin D3 and vitamin K2. In someembodiments, the oral hygiene composition includes: 1-20 wt. %hydroxyapatite, 0.00001-0.01 wt. % vitamin D3, and 0.00001-0.012 wt. %vitamin K2. In some embodiments, the composition further comprisesfluoride. In further embodiments, the oral hygiene composition includes0.01-0.5 wt. % fluoride. In further embodiments, the oral hygienecomposition includes 0.01-1.5 wt. % fluoride.

In some embodiments, the anti-inflammatory agent comprises a compound orcomposition selected from the group consisting of methylsulfonylmethane,vitamin C, cranberry seed oil, sodium gluconate, and combinationsthereof. In some embodiments, the anti-inflammatory agent comprisesmethylsulfonylmethane, vitamin C and cranberry seed oil. In someembodiments, the oral hygiene composition includes: 0.5-3 wt. %methylsulfonylmethane, 0.05-0.2 wt. % vitamin C, and 0.02-0.1 wt. %cranberry seed oil.

In some embodiments, the prebiotic agent comprises a compound orcomposition selected from the group consisting of inulin, xylitol,erythritol, cranberry seed oil, xanthan gum, stevia leaf extract, andcombinations thereof. In some embodiments, the prebiotic agent comprisesinulin, xylitol, and erythritol. In some embodiments, the oral hygienecomposition includes: 3-7 wt. % inulin, 5-20 wt. % xylitol, and 5-10 wt.% erythritol. In some embodiments, the composition further comprisescranberry seed oil. In further embodiments, the oral hygiene compositionincludes 0.02-0.1 wt. % cranberry seed oil.

In some embodiments, the alkalizing agent comprises a compound selectedfrom the group consisting of sodium bicarbonate, xylitol, erythritol,and combinations thereof. In some embodiments, the alkalizing agentcomprises sodium bicarbonate, xylitol and erythritol. In someembodiments, the oral hygiene composition includes: 0.5-3.0 wt. % sodiumbicarbonate, 5-20 wt. % xylitol and 5-10 wt. % erythritol.

In some embodiments, the composition further comprises a solvent. Insome embodiments, the solvent comprises a compound selected from thegroup consisting of water, glycerin, and combinations thereof. In someembodiments, the solvent comprises water and glycerin. In someembodiments, the oral hygiene composition includes: 15-75 wt. % waterand 1-20 wt. % glycerin.

In some embodiments, wherein composition further comprises a cleaningagent. In some embodiments, the cleaning agent comprises a compound orcomposition selected from the group consisting of hydrated silica,quillaja saponaria extract, and combinations thereof. In someembodiments, the cleaning agent comprises hydrated silica and quillajasaponaria extract. In some embodiments, the oral hygiene compositionincludes: 10-20 wt. % hydrated silica and 0.1-2 wt. % quillaja saponariaextract.

In some embodiments, wherein composition further comprises a flavoringagent. In some embodiments, the flavoring agent comprises a compound orcomposition selected from the group consisting of xylitol, erythritol,stevia, peppermint flavor, spearmint flavor, strawberry flavor, vanillaflavor, chocolate flavor, cherry flavor, blueberry flavor, bubblegumflavor, grape flavor, apricot flavor, clove, ginger, wintergreen flavor,mango flavor, fennel, orange flavor, black currant flavor, watermelonflavor, cinnamon flavor, and combinations thereof.

In another aspect, a toothpaste composition is disclosed. The toothpastecomposition includes:

-   -   balance water;    -   10-20 wt. % hydrated silica;    -   1-20 wt. % hydroxyapatite;    -   14-25 wt. % glycerin;    -   5-15 wt. % erythritol;    -   5-25 wt. % xylitol;    -   1-10 wt. % inulin;    -   0.5-3 wt. % methylsulfonylmethane;    -   0.5-3 wt. % calcium carbonate;    -   0.1-1 wt. % quillaja saponaria extract;    -   0.02-0.1 wt. % stevia leaf extract;    -   0.2-1 wt. % dicalcium phosphate;    -   0.01-1 wt. % xanthan gum;    -   0.05-0.2 wt. % vitamin C;    -   0.1-4 wt. % sodium gluconate;    -   0.02-0.1 wt. % cranberry seed oil;    -   0.001-0.002 wt. % vitamin D3;    -   0.004-0.008 wt. % vitamin K2;    -   0.1-2 wt. % color; and    -   0.1-0.5 wt. % flavoring agent.

In another aspect, the toothpaste composition includes:

-   -   balance water;    -   10-20 wt. % hydrated silica;    -   1-15 wt. % hydroxyapatite;    -   14-25 wt. % glycerin;    -   5-15 wt. % erythritol;    -   5-25 wt. % xylitol;    -   3-7 wt. % inulin;    -   0.5-3 wt. % methylsulfonylmethane;    -   0.1-1 wt. % quillaja saponaria extract;    -   0.02-0.1 wt. % stevia leaf extract;    -   0.01-1 wt. % xanthan gum;    -   0.05-0.2 wt. % vitamin C;    -   0.1-4 wt. % sodium gluconate;    -   0.02-0.1 wt. % cranberry seed oil;    -   0.001-0.002 wt. % vitamin D3;    -   0.004-0.008 wt. % vitamin K2;    -   0.1-1.5 wt. % sodium fluoride;    -   0.1-2 wt. % color; and    -   0.1-0.5 wt. % flavoring agent.

In another aspect, a mouthwash composition is disclosed. The mouthwashcomposition includes:

-   -   balance water;    -   5-20 wt. % xylitol;    -   5-15 wt. % erythritol;    -   3-7 wt. % inulin;    -   0.5-20 wt. % hydroxyapatite;    -   1-5 wt. % glycerin;    -   0.1-3 wt. % sodium bicarbonate;    -   0.5-3 wt. % methylsulfonylmethane;    -   0.1-4 wt. % sodium gluconate;    -   0.05-0.5 wt. % vitamin C;    -   0.01-1 wt. % xanthan gum;    -   0.00001-0.00005 wt. % vitamin D3;    -   0.00001-0.0005 wt. % vitamin K2;    -   0.1-2 wt. % color; and    -   0.1-0.5 wt. % flavoring agent.

In another aspect, the mouthwash composition includes:

-   -   balance water;    -   5-20 wt. % xylitol;    -   5-15 wt. % erythritol;    -   3-7 wt. % inulin;    -   0.5-20 wt. % hydroxyapatite;    -   1-5 wt. % glycerin;    -   0.1-3 wt. % sodium bicarbonate;    -   0.5-3 wt. % methylsulfonylmethane;    -   0.1-4 wt. % sodium gluconate;    -   0.05-0.5 wt. % vitamin C;    -   0.01-1 wt. % xanthan gum;    -   0.01-0.5 wt. % sodium fluoride;    -   0.00001-0.00005 wt. % vitamin D3;    -   0.00001-0.0005 wt. % vitamin K2;    -   0.1-2 wt. % color; and    -   0.1-0.5 wt. % flavoring agent.

In another aspect, a mouth spray composition is disclosed. The mouthspray composition includes:

-   -   balance water;    -   5-20 wt. % xylitol;    -   5-20 wt. % erythritol;    -   3-7 wt. % inulin;    -   0.1-3 wt. % methylsulfonylmethane;    -   1-5 wt. % glycerin;    -   0.1-3 wt. % sodium bicarbonate;    -   0.1-4 wt. % sodium gluconate;    -   0.05-0.2 wt. % vitamin C;    -   0.01-1 wt. % xanthan gum; and    -   0.1-0.5 wt. % flavoring agent.

In another aspect, a dental floss device is disclosed. The dental flossdevice includes a flossing material and wherein the flossing materialincludes: a remineralization agent and a prebiotic agent.

In some embodiments, the remineralization agent comprises a compoundselected from the group consisting of hydroxyapatite, vitamin D3,vitamin K2, fluoride, calcium carbonate, dicalcium phosphate, andcombinations thereof. In some embodiments, the remineralization agentcomprises hydroxyapatite. In some embodiments, the flossing materialcomprises 1-15 wt. % of hydroxyapatite. In some embodiments, the dentalfloss device further comprises vitamin D3 and vitamin K2. In furtherembodiments, the flossing material comprises 0.1-1 wt. % of vitamin D3and 0.1-1 wt. % of vitamin K2. In some embodiments, the dental flossdevice further comprises fluoride. In further embodiments, the flossingmaterial comprises 0.1-5 wt. % of fluoride. In some embodiments, theprebiotic agent comprises a compound or composition selected from thegroup consisting of inulin, xylitol, erythritol, cranberry seed oil,xanthan gum, stevia leaf extract, and combinations thereof. In someembodiments, the prebiotic agent comprises of xylitol, erythritol, andstevia leaf extract. In some embodiments, the flossing materialincludes: 1-15 wt. % of xylitol, 1-15 wt. % of erythritol, and 1-15 wt.% of stevia leaf extract. In some embodiments, the flossing materialincludes: 1-5 wt. % of hydroxyapatite, 0.5-3.5 wt. % of xylitol, 0.1-3wt. % of erythritol, and 0.1-3 wt. % of stevia leaf extract.

In some embodiments, the flossing material further comprises a wax. Infurther embodiments, the wax comprises beeswax.

In another aspect, a method of treating a condition in a subject,preventing a condition in a subject or promoting oral hygiene in asubject, including administering the composition or device describedherein to an oral cavity or tooth of the subject. In some embodiments,the subject is a child.

In some embodiments, the condition is a bone growth deficiency within amouth or nose of the subject. In some embodiments, the condition isharmful bacterial growth within the oral cavity. In some embodiments,the promotion is beneficial bacterial growth within the oral cavity. Insome embodiments, the condition is gingiva inflammation within the oralcavity. In some embodiments, the condition is tooth decay within theoral cavity. In some embodiments, the condition is a toothmineralization deficiency. In some embodiments, the condition is a bonemineralization deficiency. In some embodiments, the condition is a gumdisease and halitosis. In some embodiments, the promotion is teethwhitening. In some embodiments, the promotion is teeth buffering againstacidic erosion. In some embodiments, the condition is tooth or rootsensitivity.

In another aspect, a kit is described. The kit includes the compositionor device described herein.

DETAILED DESCRIPTION

Oral hygiene compositions of the present disclosure may be used toprevent cavities, remineralize teeth from outside and inside, naturallywhiten teeth, reduce tooth sensitivity, reduce tartar and calculusbuildup, promote beneficial oral bacteria, and promote the long-termhealth of teeth and the mouth of an individual. The oral hygienecompositions of the present disclosure may also be used to treat orprevent gum disease and/or halitosis, balance oral or mouth pH, andprotect teeth against acidic erosion. Moreover, such oral hygienecompositions may also aid in the development and growth of anindividual's jaws and/or nasal septum. In some embodiments, the oralhygiene composition may include a remineralization agent or material,nutrients for teeth and bone growth and development, ananti-inflammatory agent or material, a prebiotic agent material, analkalizing agent or material, or a mixture thereof.

Hydroxyapatite is a calcium mineral (e.g. calcium phosphate) that mayhelp with remineralization of enamel, or the outside of teeth whereenamel is present. However, within the teeth are living structures thatrequire calcium to grow and defend against damage. For these interiorstructures of the teeth as well as the bones (e.g. jaw bones in themouth/face and the nasal septum area), vitamin A, vitamin K (e.g.vitamin K2) and/or vitamin D (e.g. vitamin D3) may aid in the transferof calcium to within the internal structures of the teeth, bone and/ornose. However, a large number of individuals are deficient in vitamin K(e.g. vitamin K2) and/or vitamin D (e.g. vitamin D3), and as suchcalcium deposition to teeth, bone and/or nose is limited even withadditional calcium intake. As such, the oral hygiene compositions of thepresent disclosure allow remineralization of teeth and bones from theinside, and may further aid in the remineralization of teeth from theoutside. This remineralization may also assist in healthy jawbone andnose grow, reduce the likelihood of dental crowding, and reduce thelikelihood of nasal septum deviation.

As an example, in some embodiments, the oral hygiene compositionincludes:

-   -   a remineralization agent,    -   an anti-inflammatory agent,    -   a prebiotic agent, and    -   an alkalizing agent.

As another example, in some embodiments, the oral hygiene compositionincludes:

-   -   a remineralization agent,    -   an anti-inflammatory agent, and    -   a prebiotic agent.

As another example, in some embodiments, the oral hygiene compositionincludes:

-   -   an anti-inflammatory agent,    -   a prebiotic agent, and    -   an alkalizing agent.

As another example, in some embodiments, the oral hygiene compositionincludes:

-   -   a remineralization agent, and    -   a prebiotic agent.

Remineralization agents are generally used to whiten teeth, promotetooth translucency and glossiness, reduce sensitivity and pain, reducerisk of cavities, remineralize demineralized enamel, repair damage,remineralize dentin, and/or minimizes gum bleeding. Remineralizationagents may include one or a grouping of nutrients necessary for teethand bone growth and development. In some embodiments, theremineralization agent may be selected from hydroxyapatite, vitamin D(e.g., vitamin D3), vitamin K (e.g., vitamin K2), calcium carbonate,dicalcium phosphate, fluoride, or a mixture thereof. In someembodiments, the remineralization agent may comprise hydroxyapatite,vitamin D and vitamin K. In some embodiments, the remineralization agentmay comprise hydroxyapatite and vitamin D. In some embodiments, theremineralization agent may comprise hydroxyapatite and vitamin K. Insome embodiments, the remineralization agent may comprisehydroxyapatite. In some embodiments, the remineralization agent maycomprise fluoride. In some embodiments, the remineralization agent maycomprise fluoride and hydroxyapatite. In some embodiments, theremineralization agent may comprise fluoride and vitamin D. In someembodiments, the remineralization agent may comprise fluoride andvitamin K. In some embodiments, the remineralization agent may comprisefluoride, hydroxyapatite, vitamin D and vitamin K. In some embodiments,fluoride is sodium fluoride. In some embodiments, vitamin D is vitaminD3. In some embodiments, vitamin K is vitamin K2.

Hydroxyapatite may be utilized to assist tooth remineralization, toothwhitening, promote tooth translucency and glossiness, reduce toothsensitivity and pain, reduce risk of cavities, promote growth anddevelopment of teeth from outside and inside, and bone, and/or minimizegum bleeding. In some embodiments, the composition compriseshydroxyapatite of, of about, of at least, or at least about, 0.01 wt. %,0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %,0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt. %,1.2 wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8wt. %, 1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt. %,2.5 wt. %, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3 wt. %, 3.1 wt.%, 3.2 wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %, 3.7 wt. %, 3.8wt. %, 3.9 wt. %, 4 wt. %, 4.1 wt. %, 4.2 wt. %, 4.3 wt. %, 4.4 wt. %,4.5 wt. %, 4.6 wt. %, 4.7 wt. %, 4.8 wt. %, 4.9 wt. %, 5 wt. %, 5.1 wt.%, 5.2 wt. %, 5.3 wt. %, 5.4 wt. %, 5.5 wt. %, 5.6 wt. %, 5.7 wt. %, 5.8wt. %, 5.9 wt. %, 6 wt. %, 6.1 wt. %, 6.2 wt. %, 6.3 wt. %, 6.4 wt. %,6.5 wt. %, 6.6 wt. %, 6.7 wt. %, 6.8 wt. %, 6.9 wt. %, 7 wt. %, 7.1 wt.%, 7.2 wt. %, 7.3 wt. %, 7.4 wt. %, 7.5 wt. %, 7.6 wt. %, 7.7 wt. %, 7.8wt. %, 7.9 wt. %, 8 wt. %, 8.1 wt. %, 8.2 wt. %, 8.3 wt. %, 8.4 wt. %,8.5 wt. %, 8.6 wt. %, 8.7 wt. %, 8.8 wt. %, 8.9 wt. %, 9 wt. %, 9.1 wt.%, 9.2 wt. %, 9.3 wt. %, 9.4 wt. %, 9.5 wt. %, 9.6 wt. %, 9.7 wt. %, 9.8wt. %, 9.9 wt. %, 10 wt. %, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15wt. %, 16 wt. %, 17 wt. %, 18 wt. %, 19 wt. %, 20 wt. %, 21 wt. %, 22wt. %, 23 wt. %, 24 wt. %, 25 wt. %, 26 wt. %, 27 wt. %, 28 wt. %, 29wt. %, 30 wt. %, 31 wt. %, 32 wt. %, 33 wt. %, 34 wt. %, 35 wt. %, 36wt. %, 37 wt. %, 38 wt. %, 39 wt. %, 40 wt. %, 41 wt. %, 42 wt. %, 43wt. %, 44 wt. %, 45 wt. %, 46 wt. %, 47 wt. %, 48 wt. %, 49 wt. % or 50wt. %, or any range of values therebetween. For example, in someembodiments, the amount of hydroxyapatite in the composition is or isabout in any one of the following ranges: 1-20 wt. %, 5-15 wt. %, 4-16wt. %, 3-17 wt. %, 2-18 wt. %, 1-19 wt. %, 2-4 wt. %, 0.1-1 wt. %, 0.1-5wt. %, 1-5 wt. %, 5-10 wt. %, 1-10 wt. %, 10-15 wt. %, 1-15 wt. %, 10-20wt. %, 20-30 wt. %, 30-40 wt. % or 40-50 wt. % (based on total weight ofthe composition). In some embodiments, the composition is free orsubstantially free of hydroxyapatite. In some embodiments, thehydroxyapatite particles are nano-hydroxyapatite. In some embodiments,the hydroxyapatite particles are micro-hydroxyapatite. In someembodiments, the hydroxyapatite has a D₅₀ particle size distribution of,or of about, 10 nm, 20 nm, 30 nm, 40 nm, 50 nm, 60 nm, 70 nm, 80 nm, 90nm, 0.1 μm, 0.15 μm, 0.2 μm, 0.3 μm, 0.4 μm, 0.5 μm, 0.8 μm, 1 μm, 2 μm,5 μm, 8 μm, 10 μm, 15 μm, 20 μm, 25 μm, 30 μm, 40 μm, 50 μm, 75 μm, 100μm, 125 μm, 150 μm or 200 μm, or any range of values therebetween. Insome embodiments, the hydroxyapatite has a mean particle size of, or ofabout, 10 nm, 20 nm, 30 nm, 40 nm, 50 nm, 60 nm, 70 nm, 80 nm, 90 nm,0.1 μm, 0.15 μm, 0.2 μm, 0.3 μm, 0.4 μm, 0.5 μm, 0.8 μm, 1 μm, 2 μm, 5μm, 8 μm, 10 μm, 15 μm, 20 μm, 25 μm, 30 μm, 40 μm, 50 μm, 75 μm, 100μm, 125 μm, 150 μm or 200 μm, or any range of values therebetween. Insome embodiments, the hydroxyapatite particles are spherical-shaped,near spherical-shaped, acircular shaped, short bar-shaped, rod-shapedand/or needle-shaped.

Fluoride may be utilized to prevent tooth decay, strengthen enamel, andincrease the rate of remineralization. In some embodiments, thecomposition comprises fluoride of, of about, of at least, or at leastabout, 0.01 wt. %, 0.011 wt. %, 0.012 wt. %, 0.013 wt. %, 0.014 wt. %,0.015 wt. %, 0.016 wt. %, 0.017 wt. %, 0.018 wt. %, 0.019 wt. %, 0.02wt. %, 0.021 wt. %, 0.022 wt. %, 0.023 wt. %, 0.024 wt. %, 0.025 wt. %,0.026 wt. %, 0.027 wt. %, 0.028 wt. %, 0.029 wt. %, 0.03 wt. %, 0.04 wt.%, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt. %, 0.1 wt.%, 0.11 wt. %, 0.12 wt. %, 0.13 wt. %, 0.14 wt. %, 0.15 wt. %, 0.16 wt.%, 0.17 wt. %, 0.18 wt. %, 0.19 wt. %, 0.2 wt. %, 0.21 wt. %, 0.22 wt.%, 0.23 wt. %, 0.24 wt. %, 0.25 wt. %, 0.26 wt. %, 0.27 wt. %, 0.28 wt.%, 0.29 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt. %, 0.6 wt. %, 0.7 wt. %,0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt. %, 1.2 wt. %, 1.3 wt. %, 1.4 wt.%, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8 wt. %, 1.9 wt. %, 2 wt. %, 2.1wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt. %, 2.5 wt. %, 2.6 wt. %, 2.7 wt. %,2.8 wt. %, 2.9 wt. %, 3 wt. %, 3.1 wt. %, 3.2 wt. %, 3.3 wt. %, 3.4 wt.%, 3.5 wt. %, 3.6 wt. %, 3.7 wt. %, 3.8 wt. %, 3.9 wt. %, 4 wt. %, 4.1wt. %, 4.2 wt. %, 4.3 wt. %, 4.4 wt. %, 4.5 wt. %, 4.6 wt. %, 4.7 wt. %,4.8 wt. %, 4.9 wt. %, 5 wt. %, 6 wt. %, 7 wt. %, 8 wt. %, 9 wt. %, 10wt. %, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15 wt. %, 16 wt. %, 17wt. %, 18 wt. %, 19 wt. %, or 20 wt. %, or any range of valuestherebetween. For example, in some embodiments, the amount of fluoridein the composition is or is about in any one of the following ranges:0.01-0.03 wt. %, 0.019-0.021 wt. %, 0.2-0.3 wt. %, 0.22-0.26 wt. %,0.01-1 wt. %, 0.1-1 wt. %, or 1-5 wt. % (based on total weight of thecomposition). In some embodiments, the combination of fluoride andhydroxyapatite in a composition synergistically and advantageouslyincreases cavity protection and improves remineralization. In someembodiments, the composition is free or substantially free of fluoride.

Calcium carbonate and/or dicalcium phosphate may be utilized to assistin tooth remineralization. In some embodiments, the compositioncomprises calcium carbonate of, of about, of at least, or at leastabout, 0.01 wt. %, 0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.2 wt. %, 0.3 wt.%, 0.4 wt. %, 0.5 wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1wt. %, 1.1 wt. %, 1.2 wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %,1.7 wt. %, 1.8 wt. %, 1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt.%, 2.4 wt. %, 2.5 wt. %, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3wt. %, 3.1 wt. %, 3.2 wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %,3.7 wt. %, 3.8 wt. %, 3.9 wt. % or 4 wt. %, or any range of valuestherebetween. In some embodiments, the composition comprises dicalciumphosphate of, of about, of at least, or at least about, 0.01 wt. %, 0.02wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08wt. %, 0.09 wt. %, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt.%, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt. %, 1.2wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8 wt. %,1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt. %, 2.5 wt.%, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3 wt. %, 3.1 wt. %, 3.2wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %, 3.7 wt. %, 3.8 wt. %,3.9 wt. % or 4 wt. %, or any range of values therebetween. In someembodiments, the composition is free or substantially free of calciumcarbonate and/or dicalcium phosphate.

Vitamin D (e.g., vitamin D3) may be utilized to assist bone and toothmineralization, for example such as the minerals and compounds ofhydroxyapatite. In some embodiments, the composition comprises vitamin D(e.g., vitamin D3) in, in about, in at least, or in at least about,0.00001 wt. %, 0.00002 wt. %, 0.000025 wt. %, 0.00003 wt. %, 0.00004 wt.%, 0.00005 wt. %, 0.00006 wt. %, 0.00007 wt. %, 0.00008 wt. %, 0.00009wt. %, 0.0001 wt. %, 0.0002 wt. %, 0.0003 wt. %, 0.0004 wt. %, 0.0005wt. %, 0.0006 wt. %, 0.0007 wt. %, 0.0008 wt. %, 0.0009 wt. %, 0.001 wt.%, 0.0011 wt. %, 0.0012 wt. %, 0.0013 wt. %, 0.0014 wt. %, 0.0015 wt. %,0.0016 wt. %, 0.0017 wt. %, 0.0018 wt. %, 0.0019 wt. %, 0.002 wt. %,0.0025 wt. %, 0.003 wt. %, 0.0035 wt. %, 0.004 wt. %, 0.0045 wt. %,0.005 wt. %, 0.0055 wt. %, 0.006 wt. %, 0.0065 wt. %, 0.007 wt. %,0.0075 wt. %, 0.008 wt. %, 0.0085 wt. %, 0.009 wt. %, 0.0095 wt. % or0.01 wt. %, or any range of values therebetween. For example, in someembodiments, the amount of vitamin D3 in the mixture is in any one ofthe following ranges: 0.0001-0.001 wt. %, 0.001-0.002 wt. %,0.0010-0.0020 wt. %, 0.0011-0.0019 wt. %, 0.0012-0.0018 wt. %,0.0013-0.0017 wt. %, 0.0014-0.0016 wt. %, 0.002-0.003 wt. %, 0.003-0.004wt. %, 0.004-0.005 wt. %, 0.005-0.006 wt. %, 0.006-0.007 wt. %,0.007-0.008 wt. %, 0.008-0.009 wt. % or 0.009-0.01 wt. % (based on totalweight of the composition). In some embodiments, the amount of vitaminD3 in the mixture is within the daily dosage allowance of vitamin D3.

Vitamin K (e.g., vitamin K2) may assist in reducing calculus and promoteproper bone growth, reducing conditions of septum deviation.Furthermore, Vitamin K may be utilized in the composition in conjunctionwith hydroxyapatite and/or vitamin D (e.g. vitamin D3) to promote boneand tooth mineralization. In some embodiments, the composition comprisesvitamin K (e.g., vitamin K2) in, in about, in at least, or in at leastabout, 0.00001 wt. %, 0.00002 wt. %, 0.00003 wt. %, 0.00004 wt. %,0.00005 wt. %, 0.00006 wt. %, 0.00007 wt. %, 0.00008 wt. %, 0.00009 wt.%, 0.0001 wt. %, 0.0002 wt. %, 0.0003 wt. %, 0.0004 wt. %, 0.0005 wt. %,0.0006 wt. %, 0.0007 wt. %, 0.0008 wt. %, 0.0009 wt. %, 0.001 wt. %,0.0011 wt. %, 0.0012 wt. %, 0.0013 wt. %, 0.0014 wt. %, 0.0015 wt. %,0.0016 wt. %, 0.0017 wt. %, 0.0018 wt. %, 0.0019 wt. %, 0.002 wt. %,0.0021 wt. %, 0.0022 wt. %, 0.0023 wt. %, 0.0024 wt. %, 0.0025 wt. %,0.0026 wt. %, 0.0027 wt. %, 0.0028 wt. %, 0.0029 wt. %, 0.003 wt. %,0.004 wt. %, 0.005 wt. %, 0.006 wt. %, 0.007 wt. %, 0.008 wt. %, 0.009wt. %, 0.01 wt. %, 0.011 wt. %, 0.012 wt. %, 0.013 wt. %, 0.014 wt. %,0.015 wt. %, 0.016 wt. %, 0.017 wt. %, 0.018 wt. %, 0.019 wt. %, 0.02wt. %, %, 0.021 wt. %, 0.022 wt. %, 0.023 wt. %, 0.024 wt. %, 0.025 wt.%, 0.026 wt. %, 0.027 wt. %, 0.028 wt. %, 0.029 wt. %, 0.03 wt. %, %,0.031 wt. %, 0.032 wt. %, 0.033 wt. %, 0.034 wt. %, 0.035 wt. %, 0.036wt. %, 0.037 wt. %, 0.038 wt. %, 0.039 wt. %, 0.04 wt. %, %, 0.041 wt.%, 0.042 wt. %, 0.043 wt. %, 0.044 wt. %, 0.045 wt. %, 0.046 wt. %,0.047 wt. %, 0.048 wt. %, 0.049 wt. % or 0.05 wt. %, or any range ofvalues therebetween. For example, in some embodiments, the amount ofvitamin K2 in the composition is in any one of the following ranges:0.0001-0.001 wt. %, 0.001-0.002 wt. %, 0.002-0.003 wt. %, 0.003-0.012wt. %, 0.004-0.011 wt. %, 0.005-0.01 wt. %, 0.006-0.009 wt. %,0.007-0.008 wt. %, 0.01-0.02 wt. %, 0.02-0.03 wt. %, 0.03-0.04 wt. % or0.04-0.05 wt. % (based on total weight of composition). In someembodiments, the amount of vitamin K2 in the mixture is within the dailydosage allowance of vitamin K2.

In some embodiments, the molar ratio of hydroxyapatite:vitamin D (e.g.,hydroxyapatite:vitamin D3) is, is about, is greater than, or is greaterthan about, 7,000:1, 7,100:1, 7,200:1, 7,300:1, 7,400:1, 7,500:1,7,600:1, 7,650:1, 7,656:1, 7,700:1, 7,800:1, 7,900:1 or 8,000:1, or anyrange of values therebetween. For example, in some embodiments the molarratio of hydroxyapatite:vitamin D3 is about 7,600:1 to about 7,700:1, isabout 7,650:1, or is 7,656:1. In some embodiments, the molar ratio ofhydroxyapatite:vitamin K (e.g., hydroxyapatite:vitamin K2) is, is about,is greater than, or is greater than about, 1,500:1, 1,600:1, 1,700:1,1,800:1, 1,900:1, 2,000:1, 2,100:1, 2,200:1, 2,210:1, 2,212:1, 2,250:1,2,300:1, 2,400:1, 2,500:1, 2,600:1, 2,700:1, 2,800:1, 2,900:1 or3,000:1, or any range of values therebetween. For example, in someembodiments the molar ratio of hydroxyapatite:vitamin K2 is about2,100:1 to about 2,200:1, is about 2,210:1, or is 2,212:1. In someembodiments, the molar ratio of vitamin D:vitamin K (e.g., vitaminD3:vitamin K2) is, is about, is greater than, or is greater than about,15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1,2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12,1:13, 1:14 or 1:15, or any range of values therebetween. For example, insome embodiments the molar ratio of vitamin D3:vitamin K2 is about 1:1to about 1:15, is about 1:5, or is 1:10. In some embodiments,recommended daily allowance of vitamin D3 and vitamin K2 are used todetermine the molar ratio and/or amounts of vitamin D3 and vitamin K2.

Vitamin A may be utilized to promote gum health and as a nutrient fortooth enamel. Vitamin A may also be utilized in conjunction withhydroxyapatite, Vitamin D (e.g., vitamin D3), and Vitamin K (e.g.,vitamin K2) to assist bone and tooth mineralization. In someembodiments, the composition comprises vitamin A in, in about, in atleast, or in at least about, 0.00001 wt. %, 0.00002 wt. %, 0.00003 wt.%, 0.00004 wt. %, 0.00005 wt. %, 0.00006 wt. %, 0.00007 wt. %, 0.00008wt. %, 0.00009 wt. %, 0.0001 wt. %, 0.0002 wt. %, 0.0003 wt. %, 0.0004wt. %, 0.0005 wt. %, 0.0006 wt. %, 0.0007 wt. %, 0.0008 wt. %, 0.0009wt. %, 0.001 wt. %, 0.0011 wt. %, 0.0012 wt. %, 0.0013 wt. %, 0.0014 wt.%, 0.0015 wt. %, 0.0016 wt. %, 0.0017 wt. %, 0.0018 wt. %, 0.0019 wt. %,0.002 wt. %, 0.0021 wt. %, 0.0022 wt. %, 0.0023 wt. %, 0.0024 wt. %,0.0025 wt. %, 0.0026 wt. %, 0.0027 wt. %, 0.0028 wt. %, 0.0029 wt. %,0.003 wt. %, 0.004 wt. %, 0.005 wt. %, 0.006 wt. %, 0.007 wt. %, 0.008wt. %, 0.009 wt. %, 0.01 wt. %, 0.011 wt. %, 0.012 wt. %, 0.013 wt. %,0.014 wt. %, 0.015 wt. %, 0.016 wt. %, 0.017 wt. %, 0.018 wt. %, 0.019wt. %, 0.02 wt. %, %, 0.021 wt. %, 0.022 wt. %, 0.023 wt. %, 0.024 wt.%, 0.025 wt. %, 0.026 wt. %, 0.027 wt. %, 0.028 wt. %, 0.029 wt. %, 0.03wt. %, %, 0.031 wt. %, 0.032 wt. %, 0.033 wt. %, 0.034 wt. %, 0.035 wt.%, 0.036 wt. %, 0.037 wt. %, 0.038 wt. %, 0.039 wt. %, 0.04 wt. %, %,0.041 wt. %, 0.042 wt. %, 0.043 wt. %, 0.044 wt. %, 0.045 wt. %, 0.046wt. %, 0.047 wt. %, 0.048 wt. %, 0.049 wt. % or 0.05 wt. %, or any rangeof values therebetween. For example, in some embodiments, the amount ofvitamin A in the mixture is in any one of the following ranges:0.0001-0.001 wt. %, 0.001-0.002 wt. %, 0.0010-0.0020 wt. %,0.0011-0.0019 wt. %, 0.0012-0.0018 wt. %, 0.0013-0.0017 wt. %,0.0014-0.0016 wt. %, 0.002-0.003 wt. %, 0.003-0.004 wt. %, 0.004-0.005wt. %, 0.005-0.006 wt. %, 0.006-0.007 wt. %, 0.007-0.008 wt. %,0.008-0.009 wt. % or 0.009-0.01 wt. % (based on total weight of thecomposition). In some embodiments, the amount of vitamin A in themixture is within the daily dosage allowance of vitamin A.

Anti-inflammatory agents are generally used to reduce gingivalinflammation, reduce periodontal pain, and promote overall gingivahealth. In some embodiments, the anti-inflammatory agents may beselected from methylsulfonylmethane, vitamin C, cranberry seed oil,sodium gluconate, or a mixture thereof. In some embodiments, theanti-inflammatory agents may comprise methylsulfonylmethane, vitamin Cand cranberry seed oil. In some embodiments, the anti-inflammatoryagents may comprise methylsulfonylmethane and vitamin C. In someembodiments, the anti-inflammatory agents may comprisemethylsulfonylmethane and cranberry seed oil. In some embodiments, theanti-inflammatory agents may comprise vitamin C and cranberry seed oil.

Methylsulfonylmethane may be utilized to assist in reducinginflammation, promote the immune system, and/or combat microbialinfections. In some embodiments, the composition comprisesmethylsulfonylmethane of, of about, of at least, or at least about, 0.01wt. %, 0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07wt. %, 0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt.%, 0.5 wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1wt. %, 1.2 wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %,1.8 wt. %, 1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt.%, 2.5 wt. %, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3 wt. %, 3.1wt. %, 3.2 wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %, 3.7 wt. %,3.8 wt. %, 3.9 wt. %, 4 wt. %, 4.1 wt. %, 4.2 wt. %, 4.3 wt. %, 4.4 wt.%, 4.5 wt. %, 4.6 wt. %, 4.7 wt. %, 4.8 wt. %, 4.9 wt. % or 5 wt. %, orany range of values therebetween. For example, in some embodiments, theamount of methylsulfonylmethane in the composition is or is about in anyone of the following ranges: 0.01-0.1 wt. %, 0.1-0.5 wt. %, 0.5-1 wt. %,0.1-1 wt. %, 0.1-1.5 wt. % or 1-5 wt. % (based on total weight of thecomposition).

Vitamin C may be utilized to assist in reducing inflammation, strengthengums and soft tissues and prevent gum disease. In some embodiments, thecomposition comprises vitamin C of, of about, of at least, or at leastabout, 0.001 wt. %, 0.002 wt. %, 0.003 wt. %, 0.004 wt. %, 0.005 wt. %,0.006 wt. %, 0.007 wt. %, 0.008 wt. %, 0.009 wt. %, 0.01 wt. %, 0.02 wt.%, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08 wt.%, 0.09 wt. %, 0.1 wt. %, 0.11 wt. %, 0.12 wt. %, 0.13 wt. %, 0.14 wt.%, 0.15 wt. %, 0.16 wt. %, 0.17 wt. %, 0.18 wt. %, 0.19 wt. %, 0.2 wt.%, 0.21 wt. %, 0.22 wt. %, 0.23 wt. %, 0.24 wt. %, 0.25 wt. %, 0.26 wt.%, 0.27 wt. %, 0.28 wt. %, 0.29 wt. %, 0.3 wt. %, 0.31 wt. %, 0.32 wt.%, 0.33 wt. %, 0.34 wt. %, 0.35 wt. %, 0.36 wt. %, 0.37 wt. %, 0.38 wt.%, 0.39 wt. %, 0.4 wt. %, 0.41 wt. %, 0.42 wt. %, 0.43 wt. %, 0.44 wt.%, 0.45 wt. %, 0.46 wt. %, 0.47 wt. %, 0.48 wt. %, 0.49 wt. %, 0.5 wt.%, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt. %, 1.2wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8 wt. %,1.9 wt. % or 2 wt. %, or any range of values therebetween. For example,in some embodiments, the amount of vitamin C in the composition is or isabout in any one of the following ranges: 0.01-0.1 wt. %, 0.1-0.5 wt. %,0.5-1 wt. %, 0.01-1 wt. %, 0.1-1 wt. % or 1-5 wt. % (based on totalweight of the composition).

Cranberry seed oil may be utilized to assist in reducing inflammationand/or as a prebiotic. In some embodiments, the composition comprisescranberry seed oil of, of about, of at least, or at least about, 0.001wt. %, 0.002 wt. %, 0.003 wt. %, 0.004 wt. %, 0.005 wt. %, 0.006 wt. %,0.007 wt. %, 0.008 wt. %, 0.009 wt. %, 0.01 wt. %, 0.02 wt. %, 0.03 wt.%, 0.031 wt. %, 0.032 wt. %, 0.033 wt. %, 0.034 wt. %, 0.035 wt. %,0.036 wt. %, 0.037 wt. %, 0.038 wt. %, 0.039 wt. %, 0.04 wt. %, 0.041wt. %, 0.042 wt. %, 0.043 wt. %, 0.044 wt. %, 0.045 wt. %, 0.046 wt. %,0.047 wt. %, 0.048 wt. %, 0.049 wt. %, 0.05 wt. %, 0.051 wt. %, 0.052wt. %, 0.053 wt. %, 0.054 wt. %, 0.055 wt. %, 0.056 wt. %, 0.057 wt. %,0.058 wt. %, 0.059 wt. %, 0.06 wt. %, 0.061 wt. %, 0.062 wt. %, 0.063wt. %, 0.064 wt. %, 0.065 wt. %, 0.066 wt. %, 0.067 wt. %, 0.068 wt. %,0.069 wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.11 wt. %,0.12 wt. %, 0.13 wt. %, 0.14 wt. %, 0.15 wt. %, 0.16 wt. %, 0.17 wt. %,0.18 wt. %, 0.19 wt. %, 0.2 wt. %, 0.21 wt. %, 0.22 wt. %, 0.23 wt. %,0.24 wt. %, 0.25 wt. %, 0.26 wt. %, 0.27 wt. %, 0.28 wt. %, 0.29 wt. %,0.3 wt. %, 0.31 wt. %, 0.32 wt. %, 0.33 wt. %, 0.34 wt. %, 0.35 wt. %,0.36 wt. %, 0.37 wt. %, 0.38 wt. %, 0.39 wt. %, 0.4 wt. %, 0.41 wt. %,0.42 wt. %, 0.43 wt. %, 0.44 wt. %, 0.45 wt. %, 0.46 wt. %, 0.47 wt. %,0.48 wt. %, 0.49 wt. %, 0.5 wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9wt. %, 1 wt. %, 2 wt. %, 3 wt. %, 4 wt. % or 5 wt. %, or any range ofvalues therebetween. For example, in some embodiments, the amount ofcranberry seed oil in the composition is or is about in any one of thefollowing ranges: 0.001-0.01 wt. %, 0.01-0.1 wt. %, 0.1-1 wt. %, 0.01-1wt. %, 0.001-0.1 wt. % or 1-5 wt. % (based on total weight of thecomposition).

In some embodiments, the molar ratio of methylsulfonylmethane:vitamin Cis, is about, is greater than, or is greater than about, 20:1, 19:1,18.7:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9.3:1,9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1 or 1:1, or any range of valuestherebetween. For example, in some embodiments the molar ratio ofmethylsulfonylmethane:vitamin C is about 20:1 to about 16:1, is about11:1 to about 9:1, is about 6:1 to about 4:1, is about 18:1, is about10:1, is about 5:1, is 18.7:1 or is 9.3:1. In some embodiments,recommended daily allowance of vitamin C is used to determine the molarratio and/or amounts of vitamin C and methylsulfonylmethane.

A gluconate salt (e.g., sodium gluconate) may be utilized to preventtooth decay and the growth of microbes. In some embodiments, thecomposition comprises a gluconate salt of, of about, of at least, or atleast about, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt. %, 0.6wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt. %, 1.2 wt. %,1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8 wt. %, 1.9wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt. %, 2.5 wt. %,2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3 wt. %, 4 wt. %, 5 wt. %, 6wt. %, 7 wt. %, 8 wt. %, 9 wt. % or 10 wt. %, or any range of valuestherebetween. For example, in some embodiments, the amount of agluconate salt (e.g., sodium gluconate) in the composition is or isabout in any one of the following ranges: 1-2 wt. %, 2-5 wt. %, 1.5-2.5wt. % or 1-5 wt. % (based on total weight of the composition).

Prebiotic agents are generally used to promote beneficial oral bacteria,promote the long-term health of teeth and gums, and reduce bad breath.In some embodiments, the prebiotic agents may be selected from inulin,xylitol, erythritol, cranberry seed oil, xanthan gum, stevia leafextract, or a mixture thereof. In some embodiments, the prebiotic agentsmay comprise xylitol, erythritol, stevia leaf extract, or a mixturethereof. In some embodiments, the prebiotic agents may comprise inulin,xylitol, erythritol, and cranberry seed oil. In some embodiments, theprebiotic agents may comprise xylitol, erythritol, and stevia leafextract. In some embodiments, the prebiotic agents may comprise inulin,xylitol, and erythritol. In some embodiments, the prebiotic agents maycomprise inulin and xylitol. In some embodiments, the prebiotic agentsmay comprise inulin and erythritol. In some embodiments, the prebioticagents may comprise inulin and cranberry seed oil. In some embodiments,the prebiotic agents may comprise xylitol, erythritol, and cranberryseed oil. In some embodiments, the prebiotic agents may comprise xylitoland erythritol. In some embodiments, the prebiotic agents may comprisexylitol and cranberry seed oil. In some embodiments, the prebioticagents may comprise erythritol and cranberry seed oil. In someembodiments, the prebiotic agents may comprise xylitol and stevia leafextract. In some embodiments, the prebiotic agents may compriseerythritol and stevia leaf extract.

Inulin may be utilized as a prebiotic and/or to reduce halitosis. Insome embodiments, the composition comprises inulin of, of about, of atleast, or at least about, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %,0.5 wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt.%, 1.2 wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8wt. %, 1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt. %,2.5 wt. %, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3 wt. %, 3.1 wt.%, 3.2 wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %, 3.7 wt. %, 3.8wt. %, 3.9 wt. %, 4 wt. %, 4.1 wt. %, 4.2 wt. %, 4.3 wt. %, 4.4 wt. %,4.5 wt. %, 4.6 wt. %, 4.7 wt. %, 4.8 wt. %, 4.9 wt. %, 5 wt. %, 5.1 wt.%, 5.2 wt. %, 5.3 wt. %, 5.4 wt. %, 5.5 wt. %, 5.6 wt. %, 5.7 wt. %, 5.8wt. %, 5.9 wt. %, 6 wt. %, 6.1 wt. %, 6.2 wt. %, 6.3 wt. %, 6.4 wt. %,6.5 wt. %, 6.6 wt. %, 6.7 wt. %, 6.8 wt. %, 6.9 wt. %, 7 wt. %, 7.1 wt.%, 7.2 wt. %, 7.3 wt. %, 7.4 wt. %, 7.5 wt. %, 7.6 wt. %, 7.7 wt. %, 7.8wt. %, 7.9 wt. %, 8 wt. %, 8.1 wt. %, 8.2 wt. %, 8.3 wt. %, 8.4 wt. %,8.5 wt. %, 8.6 wt. %, 8.7 wt. %, 8.8 wt. %, 8.9 wt. %, 9 wt. %, 9.1 wt.%, 9.2 wt. %, 9.3 wt. %, 9.4 wt. %, 9.5 wt. %, 9.6 wt. %, 9.7 wt. %, 9.8wt. %, 9.9 wt. %, 10 wt. %, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15wt. %, 16 wt. %, 17 wt. %, 18 wt. %, 19 wt. % or 20 wt. %, or any rangeof values therebetween. For example, in some embodiments, the amount ofinulin in the composition is or is about in any one of the followingranges: 0.1-1 wt. %, 1-5 wt. %, 5-10 wt. %, 1-10 wt. %, 10-20 wt. %, 2-8wt. %, 3-7 wt. % or 4-6 wt. % (based on total weight of thecomposition).

Xylitol may be utilized as a prebiotic, flavoring agent, alkalizingagent, buffering agent, and/or to reduce cavities. In some embodiments,the composition comprises xylitol of, of about, of at least, or at leastabout, 0.01 wt. %, 0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.2 wt. %, 0.3 wt.%, 0.4 wt. %, 0.5 wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1wt. %, 1.1 wt. %, 1.2 wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %,1.7 wt. %, 1.8 wt. %, 1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt.%, 2.4 wt. %, 2.5 wt. %, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3wt. %, 3.1 wt. %, 3.2 wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %,3.7 wt. %, 3.8 wt. %, 3.9 wt. %, 4 wt. %, 4.1 wt. %, 4.2 wt. %, 4.3 wt.%, 4.4 wt. %, 4.5 wt. %, 4.6 wt. %, 4.7 wt. %, 4.8 wt. %, 4.9 wt. %, 5wt. %, 5.1 wt. %, 5.2 wt. %, 5.3 wt. %, 5.4 wt. %, 5.5 wt. %, 5.6 wt. %,5.7 wt. %, 5.8 wt. %, 5.9 wt. %, 6 wt. %, 6.1 wt. %, 6.2 wt. %, 6.3 wt.%, 6.4 wt. %, 6.5 wt. %, 6.6 wt. %, 6.7 wt. %, 6.8 wt. %, 6.9 wt. %, 7wt. %, 7.1 wt. %, 7.2 wt. %, 7.3 wt. %, 7.4 wt. %, 7.5 wt. %, 7.6 wt. %,7.7 wt. %, 7.8 wt. %, 7.9 wt. %, 8 wt. %, 8.1 wt. %, 8.2 wt. %, 8.3 wt.%, 8.4 wt. %, 8.5 wt. %, 8.6 wt. %, 8.7 wt. %, 8.8 wt. %, 8.9 wt. %, 9wt. %, 9.1 wt. %, 9.2 wt. %, 9.3 wt. %, 9.4 wt. %, 9.5 wt. %, 9.6 wt. %,9.7 wt. %, 9.8 wt. %, 9.9 wt. %, 10 wt. %, 11 wt. %, 12 wt. %, 13 wt. %,14 wt. %, 15 wt. %, 16 wt. %, 17 wt. %, 18 wt. %, 19 wt. %, 20 wt. %, 21wt. %, 22 wt. %, 23 wt. %, 24 wt. % or 25 wt. %, or any range of valuestherebetween. For example, in some embodiments, the amount of xylitol inthe composition is or is about in any one of the following ranges: 0.1-1wt. %, 0.1-5 wt. %, 1-3 wt. %, 1-5 wt. %, 5-10 wt. %, 1-15 wt. %, 15-20wt. %, 20-25 wt. %, 5-20 wt. %, 10-15 wt. %, 9-11 wt. % or 14-16 wt. %(based on total weight of the composition).

Erythritol may be utilized as a prebiotic, flavoring agent, alkalizingagent, buffering agent, for its cooling effect, and/or to reducecavities. In some embodiments, the composition comprises erythritol of,of about, of at least, or at least about, 0.01 wt. %, 0.02 wt. %, 0.03wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08 wt. %, 0.09wt. %, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt. %, 0.6 wt. %,0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.1 wt. %, 1.2 wt. %, 1.3 wt.%, 1.4 wt. %, 1.5 wt. %, 1.6 wt. %, 1.7 wt. %, 1.8 wt. %, 1.9 wt. %, 2wt. %, 2.1 wt. %, 2.2 wt. %, 2.3 wt. %, 2.4 wt. %, 2.5 wt. %, 2.6 wt. %,2.7 wt. %, 2.8 wt. %, 2.9 wt. %, 3 wt. %, 3.1 wt. %, 3.2 wt. %, 3.3 wt.%, 3.4 wt. %, 3.5 wt. %, 3.6 wt. %, 3.7 wt. %, 3.8 wt. %, 3.9 wt. %, 4wt. %, 4.1 wt. %, 4.2 wt. %, 4.3 wt. %, 4.4 wt. %, 4.5 wt. %, 4.6 wt. %,4.7 wt. %, 4.8 wt. %, 4.9 wt. %, 5 wt. %, 5.1 wt. %, 5.2 wt. %, 5.3 wt.%, 5.4 wt. %, 5.5 wt. %, 5.6 wt. %, 5.7 wt. %, 5.8 wt. %, 5.9 wt. %, 6wt. %, 6.1 wt. %, 6.2 wt. %, 6.3 wt. %, 6.4 wt. %, 6.5 wt. %, 6.6 wt. %,6.7 wt. %, 6.8 wt. %, 6.9 wt. %, 7 wt. %, 7.1 wt. %, 7.2 wt. %, 7.3 wt.%, 7.4 wt. %, 7.5 wt. %, 7.6 wt. %, 7.7 wt. %, 7.8 wt. %, 7.9 wt. %, 8wt. %, 8.1 wt. %, 8.2 wt. %, 8.3 wt. %, 8.4 wt. %, 8.5 wt. %, 8.6 wt. %,8.7 wt. %, 8.8 wt. %, 8.9 wt. %, 9 wt. %, 9.1 wt. %, 9.2 wt. %, 9.3 wt.%, 9.4 wt. %, 9.5 wt. %, 9.6 wt. %, 9.7 wt. %, 9.8 wt. %, 9.9 wt. %, 10wt. %, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15 wt. %, 16 wt. %, 17wt. %, 18 wt. %, 19 wt. %, 20 wt. %, 21 wt. %, 22 wt. %, 23 wt. %, 24wt. % or 25 wt. %, or any range of values therebetween. For example, insome embodiments, the amount of erythritol in the composition is or isabout in any one of the following ranges: 0.01-1 wt. %, 0.1-1 wt. %,0.1-5 wt. %, 0.5-2.5 wt. %, 0.1-3 wt. %, 0.01-3 wt. %, 1-5 wt. %, 5-10wt. %, 10-15 wt. %, 15-20 wt. %, 20-25 wt. %, 5-20 wt. %, 1-15 wt. %,9-11 wt. % or 14-16 wt. % (based on total weight of the composition).

Cranberry seed oil may also be utilized as a prebiotic. In someembodiments, the composition comprises cranberry seed oil of, of about,of at least, or at least about, 0.001 wt. %, 0.002 wt. %, 0.003 wt. %,0.004 wt. %, 0.005 wt. %, 0.006 wt. %, 0.007 wt. %, 0.008 wt. %, 0.009wt. %, 0.01 wt. %, 0.02 wt. %, 0.03 wt. %, 0.031 wt. %, 0.032 wt. %,0.033 wt. %, 0.034 wt. %, 0.035 wt. %, 0.036 wt. %, 0.037 wt. %, 0.038wt. %, 0.039 wt. %, 0.04 wt. %, 0.041 wt. %, 0.042 wt. %, 0.043 wt. %,0.044 wt. %, 0.045 wt. %, 0.046 wt. %, 0.047 wt. %, 0.048 wt. %, 0.049wt. %, 0.05 wt. %, 0.051 wt. %, 0.052 wt. %, 0.053 wt. %, 0.054 wt. %,0.055 wt. %, 0.056 wt. %, 0.057 wt. %, 0.058 wt. %, 0.059 wt. %, 0.06wt. %, 0.061 wt. %, 0.062 wt. %, 0.063 wt. %, 0.064 wt. %, 0.065 wt. %,0.066 wt. %, 0.067 wt. %, 0.068 wt. %, 0.069 wt. %, 0.07 wt. %, 0.08 wt.%, 0.09 wt. %, 0.1 wt. %, 0.11 wt. %, 0.12 wt. %, 0.13 wt. %, 0.14 wt.%, 0.15 wt. %, 0.16 wt. %, 0.17 wt. %, 0.18 wt. %, 0.19 wt. %, 0.2 wt.%, 0.21 wt. %, 0.22 wt. %, 0.23 wt. %, 0.24 wt. %, 0.25 wt. %, 0.26 wt.%, 0.27 wt. %, 0.28 wt. %, 0.29 wt. %, 0.3 wt. %, 0.31 wt. %, 0.32 wt.%, 0.33 wt. %, 0.34 wt. %, 0.35 wt. %, 0.36 wt. %, 0.37 wt. %, 0.38 wt.%, 0.39 wt. %, 0.4 wt. %, 0.41 wt. %, 0.42 wt. %, 0.43 wt. %, 0.44 wt.%, 0.45 wt. %, 0.46 wt. %, 0.47 wt. %, 0.48 wt. %, 0.49 wt. %, 0.5 wt.%, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 2 wt. %, 3 wt.%, 4 wt. % or 5 wt. %, or any range of values therebetween. For example,in some embodiments, the amount of cranberry seed oil in the compositionis or is about in any one of the following ranges: 0.001-0.01 wt. %,0.01-0.1 wt. %, 0.1-1 wt. %, 0.01-1 wt. %, 0.001-0.1 wt. % or 1-5 wt. %(based on total weight of the composition).

Stevia leaf extract may also be utilized as a prebiotic and/or may beutilized as a source of vitamins and minerals. In some embodiments, theprebiotic agent comprises stevia leaf extract of, of about, of at least,or at least about, 0.01 wt. %, 0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05wt. %, 0.06 wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.2wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt. %, 0.6 wt. %, 0.7 wt. %, 0.8 wt. %,0.9 wt. %, 1 wt. %, 1.1 wt. %, 1.2 wt. %, 1.3 wt. %, 1.4 wt. %, 1.5 wt.%, 1.6 wt. %, 1.7 wt. %, 1.8 wt. %, 1.9 wt. %, 2 wt. %, 2.1 wt. %, 2.2wt. %, 2.3 wt. %, 2.4 wt. %, 2.5 wt. %, 2.6 wt. %, 2.7 wt. %, 2.8 wt. %,2.9 wt. %, 3 wt. %, 3.1 wt. %, 3.2 wt. %, 3.3 wt. %, 3.4 wt. %, 3.5 wt.%, 3.6 wt. %, 3.7 wt. %, 3.8 wt. %, 3.9 wt. %, 4 wt. %, 4.1 wt. %, 4.2wt. %, 4.3 wt. %, 4.4 wt. %, 4.5 wt. %, 4.6 wt. %, 4.7 wt. %, 4.8 wt. %,4.9 wt. %, 5 wt. %, 5.1 wt. %, 5.2 wt. %, 5.3 wt. %, 5.4 wt. %, 5.5 wt.%, 5.6 wt. %, 5.7 wt. %, 5.8 wt. %, 5.9 wt. %, 6 wt. %, 6.1 wt. %, 6.2wt. %, 6.3 wt. %, 6.4 wt. %, 6.5 wt. %, 6.6 wt. %, 6.7 wt. %, 6.8 wt. %,6.9 wt. %, 7 wt. %, 7.1 wt. %, 7.2 wt. %, 7.3 wt. %, 7.4 wt. %, 7.5 wt.%, 7.6 wt. %, 7.7 wt. %, 7.8 wt. %, 7.9 wt. %, 8 wt. %, 8.1 wt. %, 8.2wt. %, 8.3 wt. %, 8.4 wt. %, 8.5 wt. %, 8.6 wt. %, 8.7 wt. %, 8.8 wt. %,8.9 wt. %, 9 wt. %, 9.1 wt. %, 9.2 wt. %, 9.3 wt. %, 9.4 wt. %, 9.5 wt.%, 9.6 wt. %, 9.7 wt. %, 9.8 wt. %, 9.9 wt. %, 10 wt. %, 11 wt. %, 12wt. %, 13 wt. %, 14 wt. % or 15 wt. %, or any range of valuestherebetween. For example, in some embodiments, the amount of stevialeaf extract in the prebiotic agent is or is about in any one of thefollowing ranges: 0.01-1 wt. %, 0.1-1 wt. %, 0.1-5 wt. %, 1-5 wt. %,5-10 wt. %, 10-15 wt. %, 1-15 wt. %, 0.5-2.5 wt. %, 0.1-3 wt. % or0.01-3 wt. % (based on total weight of the composition).

Alkalizing agents are generally used to raise the pH of a solutionand/or balance and buffer the pH of a solution. In some embodiments, thealkalizing agents may be selected from sodium bicarbonate, xylitol,erythritol, or a mixture thereof. In some embodiments, the alkalizingagents may comprise sodium bicarbonate, xylitol, and erythritol. In someembodiments, the alkalizing agents may comprise sodium bicarbonate andxylitol. In some embodiments, the alkalizing agents may comprise sodiumbicarbonate and erythritol. In some embodiments, the alkalizing agentsmay comprise xylitol and erythritol.

Sodium bicarbonate may be utilized as an alkalizing agent and/or abuffering agent. In some embodiments, the composition comprises sodiumbicarbonate of, of about, of at least, or at least about, 0.01 wt. %,0.05 wt. %, 0.1 wt. %, 0.15 wt. %, 0.2 wt. %, 0.25 wt. %, 0.3 wt. %,0.35 wt. %, 0.4 wt. %, 0.45 wt. %, 0.5 wt. %, 0.55 wt. %, 0.6 wt. %,0.65 wt. %, 0.7 wt. %, 0.75 wt. %, 0.8 wt. %, 0.85 wt. %, 0.9 wt. %,0.95 wt. %, 1 wt. %, 1.05 wt. %, 1.1 wt. %, 1.15 wt. %, 1.2 wt. %, 1.25wt. %, 1.3 wt. %, 1.35 wt. %, 1.4 wt. %, 1.45 wt. %, 1.5 wt. %, 1.55 wt.%, 1.6 wt. %, 1.65 wt. %, 1.7 wt. %, 1.75 wt. %, 1.8 wt. %, 1.85 wt. %,1.9 wt. %, 1.95 wt. %, 2 wt. %, 2.05 wt. %, 2.1 wt. %, 2.15 wt. %, 2.2wt. %, 2.25 wt. %, 2.3 wt. %, 2.35 wt. %, 2.4 wt. %, 2.45 wt. %, 2.5 wt.%, 2.55 wt. %, 2.6 wt. %, 2.65 wt. %, 2.7 wt. %, 2.75 wt. %, 2.8 wt. %,2.85 wt. %, 2.9 wt. %, 2.95 wt. %, 3 wt. %, 3.05 wt. %, 3.1 wt. %, 3.15wt. %, 3.2 wt. %, 3.25 wt. %, 3.3 wt. %, 3.35 wt. %, 3.4 wt. %, 3.45 wt.%, 3.5 wt. %, 3.55 wt. %, 3.6 wt. %, 3.65 wt. %, 3.7 wt. %, 3.75 wt. %,3.8 wt. %, 3.85 wt. %, 3.9 wt. %, 3.95 wt. %, 4 wt. %, 4.05 wt. %, 4.1wt. %, 4.15 wt. %, 4.2 wt. %, 4.25 wt. %, 4.3 wt. %, 4.35 wt. %, 4.4 wt.%, 4.45 wt. %, 4.5 wt. %, 4.55 wt. %, 4.6 wt. %, 4.65 wt. %, 4.7 wt. %,4.75 wt. %, 4.8 wt. %, 4.85 wt. %, 4.9 wt. %, 4.95 wt. %, 5 wt. %, 6 wt.%, 7 wt. %, 8 wt. %, 9 wt. % or 10 wt. %, or any range of valuestherebetween. For example, in some embodiments, the amount of sodiumbicarbonate in the composition is or is about in any one of thefollowing ranges: 0.01-0.1 wt. %, 0.1-1 wt. %, 1-2 wt. %, 0.5-1.5 wt. %,1-5 wt. %, 0.1-2 wt. % or 0.1-5 wt. % (based on total weight of thecomposition).

Xylitol may also be utilized as an alkalizing agent and/or a bufferingagent. In some embodiments, the composition comprises xylitol of, ofabout, of at least, or at least about, 1 wt. %, 2 wt. %, 3 wt. %, 4 wt.%, 5 wt. %, 6 wt. %, 7 wt. %, 8 wt. %, 9 wt. %, 10 wt. %, 11 wt. %, 12wt. %, 13 wt. %, 14 wt. %, 15 wt. %, 16 wt. %, 17 wt. %, 18 wt. %, 19wt. %, 20 wt. %, 21 wt. %, 22 wt. %, 23 wt. %, 24 wt. % or 25 wt. %, orany range of values therebetween. For example, in some embodiments, theamount of xylitol in the composition is or is about in any one of thefollowing ranges: 1-5 wt. %, 5-10 wt. %, 10-15 wt. %, 15-20 wt. %, 20-25wt. %, 5-20 wt. %, 10-15 wt. %, 9-11 wt. % or 14-16 wt. % (based ontotal weight of the composition).

Erythritol may also be utilized as an alkalizing agent and/or abuffering agent. In some embodiments, the composition compriseserythritol of, of about, of at least, or at least about, 1 wt. %, 2 wt.%, 3 wt. %, 4 wt. %, 5 wt. %, 6 wt. %, 7 wt. %, 8 wt. %, 9 wt. %, 10 wt.%, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15 wt. %, 16 wt. %, 17 wt. %,18 wt. %, 19 wt. %, 20 wt. %, 21 wt. %, 22 wt. %, 23 wt. %, 24 wt. % or25 wt. %, or any range of values therebetween. For example, in someembodiments, the amount of erythritol in the composition is or is aboutin any one of the following ranges: 1-5 wt. %, 5-10 wt. %, 10-15 wt. %,15-20 wt. %, 20-25 wt. %, 5-20 wt. %, 10-15 wt. %, 9-11 wt. % or 14-16wt. % (based on total weight of the composition).

In some embodiments, the oral hygiene composition further includes asolvent. In some embodiments, the solvent may be selected from water,glycerin, or a mixture thereof. In some embodiments, the solventcomprises water and glycerin. In some embodiments, the compositioncomprises water in, in about, in at least, or in least about, 1 wt. %, 5wt. %, 10 wt. %, 15 wt. %, 20 wt. %, 25 wt. %, 30 wt. %, 35 wt. %, 40wt. %, 45 wt. %, 50 wt. %, 55 wt. %, 60 wt. %, 65 wt. %, 70 wt. %, 75wt. %, 80 wt. % or 85 wt. %, or any range of values therebetween. Forexample, in some embodiments, the amount of water in the composition isor is about in any one of the following ranges: 10-15 wt. %, 15-20 wt.%, 20-25 wt. %, 55-60 wt. %, 60-65 wt. %, 65-70 wt. % or 70-75 wt. %(based on total weight of the composition). In some embodiments, thecomposition comprises glycerin in, in about, in at least, or in at leastabout, 0.1 wt. %, 0.5 wt. %, 1 wt. %, 1.5 wt. %, 2 wt. %, 2.5 wt. %, 3wt. %, 3.5 wt. %, 4 wt. %, 4.5 wt. %, 5 wt. %, 6 wt. %, 7 wt. %, 8 wt.%, 9 wt. %, 10 wt. %, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15 wt. %,15.5 wt. %, 16 wt. %, 16.5 wt. %, 17 wt. %, 17.5 wt. %, 18 wt. %, 18.5wt. %, 19 wt. %, 19.5 wt. %, 20 wt. %, 21 wt. %, 22 wt. %, 23 wt. %, 24wt. % or 25 wt. %, or any range of values therebetween. For example, insome embodiments, the amount of glycerin in the composition is or isabout in any one of the following ranges: 0.1-1 wt. %, 1-2 wt. %, 1-3wt. %, 1-5 wt. %, 5-15 wt. %, 10-15 wt. %, 15-20 wt. %, 20-25 wt. %,5-20 wt. %, 10-15 wt. % or 16-18 wt. % (based on total weight of thecomposition). In some embodiments, the solvent is recited to be thebalance of the composition.

In some embodiments, the oral hygiene composition further includes acleaning agent, which are generally used as microscopic, abrasivepolishing agent. In some embodiments, the cleaning agent may be selectedfrom hydrated silica, quillaja saponaria extract, or a mixture thereof.In some embodiments, the cleaning agent comprises hydrated silica andquillaja saponaria extract. Hydrated silica may be utilized as athickening and/or cleaning agent. In some embodiments, the compositioncomprises hydrated silica of, of about, of at least, or at least about,1 wt. %, 2 wt. %, 3 wt. %, 4 wt. %, 5 wt. %, 6 wt. %, 7 wt. %, 8 wt. %,9 wt. %, 10 wt. %, 11 wt. %, 12 wt. %, 13 wt. %, 14 wt. %, 15 wt. %, 16wt. %, 17 wt. %, 18 wt. %, 19 wt. %, 20 wt. %, 21 wt. %, 22 wt. %, 23wt. %, 24 wt. % or 25 wt. %, or any range of values therebetween. Forexample, in some embodiments, the amount of hydrated silica in thecomposition is or is about in any one of the following ranges: 1-5 wt.%, 5-10 wt. %, 10-15 wt. %, 15-20 wt. %, 20-25 wt. %, 10-20 wt. % or14-16 wt. % (based on total weight of the composition).

Quillaja saponaria extract may be utilized as a foaming and/or cleaningagent. In some embodiments, the composition comprises quillaja saponariaextract of, of about, of at least, or at least about, 0.01 wt. %, 0.02wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08wt. %, 0.09 wt. %, 0.1 wt. %, 0.11 wt. %, 0.12 wt. %, 0.13 wt. %, 0.14wt. %, 0.15 wt. %, 0.16 wt. %, 0.17 wt. %, 0.18 wt. %, 0.19 wt. %, 0.2wt. %, 0.21 wt. %, 0.22 wt. %, 0.23 wt. %, 0.24 wt. %, 0.25 wt. %, 0.26wt. %, 0.27 wt. %, 0.28 wt. %, 0.29 wt. %, 0.3 wt. %, 0.31 wt. %, 0.32wt. %, 0.33 wt. %, 0.34 wt. %, 0.35 wt. %, 0.36 wt. %, 0.37 wt. %, 0.38wt. %, 0.39 wt. %, 0.4 wt. %, 0.41 wt. %, 0.42 wt. %, 0.43 wt. %, 0.44wt. %, 0.45 wt. %, 0.46 wt. %, 0.47 wt. %, 0.48 wt. %, 0.49 wt. %, 0.5wt. %, 0.51 wt. %, 0.52 wt. %, 0.53 wt. %, 0.54 wt. %, 0.55 wt. %, 0.56wt. %, 0.57 wt. %, 0.58 wt. %, 0.59 wt. %, 0.6 wt. %, 0.61 wt. %, 0.62wt. %, 0.63 wt. %, 0.64 wt. %, 0.65 wt. %, 0.66 wt. %, 0.67 wt. %, 0.68wt. %, 0.69 wt. %, 0.7 wt. %, 0.71 wt. %, 0.72 wt. %, 0.73 wt. %, 0.74wt. %, 0.75 wt. %, 0.76 wt. %, 0.77 wt. %, 0.78 wt. %, 0.79 wt. %, 0.8wt. %, 0.81 wt. %, 0.82 wt. %, 0.83 wt. %, 0.84 wt. %, 0.85 wt. %, 0.86wt. %, 0.87 wt. %, 0.88 wt. %, 0.89 wt. %, 0.9 wt. %, 0.91 wt. %, 0.92wt. %, 0.93 wt. %, 0.94 wt. %, 0.95 wt. %, 0.96 wt. %, 0.97 wt. %, 0.98wt. %, 0.99 wt. %, 1 wt. %, 2 wt. %, 3 wt. %, 4 wt. % or 5 wt. %, or anyrange of values therebetween. For example, in some embodiments, theamount of quillaja saponaria extract in the composition is or is aboutin any one of the following ranges: 0.01-0.1 wt. %, 0.1-1 wt. %, 1-3 wt.%, 0.1-0.5 wt. %, 0.01-0.5 wt. %, 0.2-0.4 wt. % or 0.1-0.9 wt. % (basedon total weight of the composition).

In some embodiments, the oral hygiene composition further includes aflavoring agent. Flavoring agents may be utilized to assist in providinga favorable taste and/or smell and/or as a taste masking agent. In someembodiments, the flavoring agent may be selected from xylitol,erythritol, stevia, peppermint flavor, spearmint flavor, strawberryflavor, vanilla flavor, chocolate flavor, cherry flavor, blueberryflavor, bubblegum flavor, grape flavor, apricot flavor, clove flavor,ginger flavor, wintergreen flavor, mango flavor, fennel flavor, orangeflavor, black currant flavor, watermelon flavor, cinnamon flavor, or amixture thereof. In some embodiments, the composition comprises aflavoring agent of, of about, of at least, or at least about, 0.01 wt.%, 0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt.%, 0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.11 wt. %, 0.12 wt. %, 0.13 wt.%, 0.14 wt. %, 0.15 wt. %, 0.16 wt. %, 0.17 wt. %, 0.18 wt. %, 0.19 wt.%, 0.2 wt. %, 0.21 wt. %, 0.22 wt. %, 0.23 wt. %, 0.24 wt. %, 0.25 wt.%, 0.26 wt. %, 0.27 wt. %, 0.28 wt. %, 0.29 wt. %, 0.3 wt. %, 0.31 wt.%, 0.32 wt. %, 0.33 wt. %, 0.34 wt. %, 0.35 wt. %, 0.36 wt. %, 0.37 wt.%, 0.38 wt. %, 0.39 wt. %, 0.4 wt. %, 0.41 wt. %, 0.42 wt. %, 0.43 wt.%, 0.44 wt. %, 0.45 wt. %, 0.46 wt. %, 0.47 wt. %, 0.48 wt. %, 0.49 wt.%, 0.5 wt. %, 0.51 wt. %, 0.52 wt. %, 0.53 wt. %, 0.54 wt. %, 0.55 wt.%, 0.56 wt. %, 0.57 wt. %, 0.58 wt. %, 0.59 wt. %, 0.6 wt. %, 0.61 wt.%, 0.62 wt. %, 0.63 wt. %, 0.64 wt. %, 0.65 wt. %, 0.66 wt. %, 0.67 wt.%, 0.68 wt. %, 0.69 wt. %, 0.7 wt. %, 0.71 wt. %, 0.72 wt. %, 0.73 wt.%, 0.74 wt. %, 0.75 wt. %, 0.76 wt. %, 0.77 wt. %, 0.78 wt. %, 0.79 wt.%, 0.8 wt. %, 0.81 wt. %, 0.82 wt. %, 0.83 wt. %, 0.84 wt. %, 0.85 wt.%, 0.86 wt. %, 0.87 wt. %, 0.88 wt. %, 0.89 wt. %, 0.9 wt. %, 0.91 wt.%, 0.92 wt. %, 0.93 wt. %, 0.94 wt. %, 0.95 wt. %, 0.96 wt. %, 0.97 wt.%, 0.98 wt. %, 0.99 wt. %, 1 wt. %, 2 wt. %, 3 wt. %, 4 wt. % or 5 wt.%, or any range of values therebetween. For example, in someembodiments, the amount of a flavoring agent in the composition is or isabout in any one of the following ranges: 0.01-0.1 wt. %, 0.1-0.3 wt. %,0.1-0.5 wt. %, 0.01-0.5 wt. %, 0.1-0.3 wt. % or 0.1-0.9 wt. % (based ontotal weight of the composition).

In some embodiments, the oral hygiene composition further includes acoloring agent. In some embodiments, the coloring agent is a foodcoloring agent. In some embodiments, the composition comprises acoloring agent of, of about, of at least, or at least about, 0.01 wt. %,0.02 wt. %, 0.03 wt. %, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %,0.08 wt. %, 0.09 wt. %, 0.1 wt. %, 0.11 wt. %, 0.12 wt. %, 0.13 wt. %,0.14 wt. %, 0.15 wt. %, 0.16 wt. %, 0.17 wt. %, 0.18 wt. %, 0.19 wt. %,0.2 wt. %, 0.21 wt. %, 0.22 wt. %, 0.23 wt. %, 0.24 wt. %, 0.25 wt. %,0.26 wt. %, 0.27 wt. %, 0.28 wt. %, 0.29 wt. %, 0.3 wt. %, 0.31 wt. %,0.32 wt. %, 0.33 wt. %, 0.34 wt. %, 0.35 wt. %, 0.36 wt. %, 0.37 wt. %,0.38 wt. %, 0.39 wt. %, 0.4 wt. %, 0.41 wt. %, 0.42 wt. %, 0.43 wt. %,0.44 wt. %, 0.45 wt. %, 0.46 wt. %, 0.47 wt. %, 0.48 wt. %, 0.49 wt. %,0.5 wt. %, 0.51 wt. %, 0.52 wt. %, 0.53 wt. %, 0.54 wt. %, 0.55 wt. %,0.56 wt. %, 0.57 wt. %, 0.58 wt. %, 0.59 wt. %, 0.6 wt. %, 0.61 wt. %,0.62 wt. %, 0.63 wt. %, 0.64 wt. %, 0.65 wt. %, 0.66 wt. %, 0.67 wt. %,0.68 wt. %, 0.69 wt. %, 0.7 wt. %, 0.71 wt. %, 0.72 wt. %, 0.73 wt. %,0.74 wt. %, 0.75 wt. %, 0.76 wt. %, 0.77 wt. %, 0.78 wt. %, 0.79 wt. %,0.8 wt. %, 0.81 wt. %, 0.82 wt. %, 0.83 wt. %, 0.84 wt. %, 0.85 wt. %,0.86 wt. %, 0.87 wt. %, 0.88 wt. %, 0.89 wt. %, 0.9 wt. %, 0.91 wt. %,0.92 wt. %, 0.93 wt. %, 0.94 wt. %, 0.95 wt. %, 0.96 wt. %, 0.97 wt. %,0.98 wt. %, 0.99 wt. %, 1 wt. %, 1.5 wt. %, 2 wt. %, 3 wt. %, 4 wt. % or5 wt. %, or any range of values therebetween. For example, in someembodiments, the amount of a coloring agent in the composition is or isabout in any one of the following ranges: 0.01-0.1 wt. %, 1-3 wt. %,0.1-2 wt. %, 0.5-1.5 wt. %, 0.1-0.3 wt. % or 0.1-0.9 wt. % (based ontotal weight of the composition).

Compositional Forms

The oral hygiene composition may be in the form of a toothpaste,mouthwash, or mouth spray.

In some embodiments, the oral hygiene toothpaste composition maycomprise water, hydrated silica, hydroxyapatite, glycerin, erythritol,xylitol, inulin, methylsulfonylmethane, calcium carbonate, quillajasaponaria extract, stevia leaf extract, dicalcium phosphate, xanthangum, vitamin C, sodium gluconate, cranberry seed oil, vitamin D3,vitamin K2, flavoring agent, or a mixture thereof. In some embodiments,the oral hygiene toothpaste composition may comprise water, hydratedsilica, hydroxyapatite, glycerin, erythritol, xylitol, inulin,methylsulfonylmethane, calcium carbonate, quillaja saponaria extract,stevia leaf extract, dicalcium phosphate, xanthan gum, vitamin C, sodiumgluconate, cranberry seed oil, vitamin D3, vitamin K2, and a flavoringagent. In some embodiments, the oral hygiene toothpaste composition maycomprise water, hydrated silica, hydroxyapatite, glycerin, erythritol,xylitol, inulin, methylsulfonylmethane, quillaja saponaria extract,stevia leaf extract, xanthan gum, vitamin C, sodium gluconate, cranberryseed oil, vitamin D3, vitamin K2, sodium fluoride, flavoring agent, or amixture thereof. In some embodiments, the oral hygiene toothpastecomposition may comprise water, hydrated silica, hydroxyapatite,glycerin, erythritol, xylitol, inulin, methylsulfonylmethane, quillajasaponaria extract, stevia leaf extract, xanthan gum, vitamin C, sodiumgluconate, cranberry seed oil, vitamin D3, vitamin K2, sodium fluoride,and a flavoring agent.

In some embodiments, the oral hygiene mouthwash composition may comprisewater, xylitol, erythritol, inulin, hydroxyapatite, glycerin, sodiumbicarbonate, methylsulfonylmethane, vitamin C, xanthan gum, flavoringagent, or a mixture thereof. In some embodiments, the oral hygienemouthwash composition may comprise water, xylitol, erythritol, inulin,hydroxyapatite, glycerin, sodium bicarbonate, methylsulfonylmethane,vitamin C, xanthan gum, and a flavoring agent. In some embodiments, theoral hygiene mouthwash composition may comprise water, xylitol,erythritol, inulin, hydroxyapatite, glycerin, sodium bicarbonate,methylsulfonylmethane, vitamin C, xanthan gum, sodium gluconate, vitaminD3, vitamin K2, flavoring agent, or a mixture thereof. In someembodiments, the oral hygiene mouthwash composition may comprise water,xylitol, erythritol, inulin, hydroxyapatite, glycerin, sodiumbicarbonate, methylsulfonylmethane, vitamin C, xanthan gum, sodiumgluconate, vitamin D3, vitamin K2, and a flavoring agent. In someembodiments, the oral hygiene mouthwash composition may comprise water,xylitol, erythritol, inulin, hydroxyapatite, glycerin, sodiumbicarbonate, methylsulfonylmethane, vitamin C, xanthan gum, sodiumgluconate, sodium fluoride, vitamin D3, vitamin K2, flavoring agent, ora mixture thereof. In some embodiments, the oral hygiene mouthwashcomposition may comprise water, xylitol, erythritol, inulin,hydroxyapatite, glycerin, sodium bicarbonate, methylsulfonylmethane,vitamin C, xanthan gum, sodium gluconate, sodium fluoride, vitamin D3,vitamin K2, and a flavoring agent.

In some embodiments, the oral hygiene mouth spray composition maycomprise water, xylitol, erythritol, inulin, methylsulfonylmethane,glycerin, sodium bicarbonate, vitamin C, xanthan gum, flavoring agent,or a mixture thereof. In some embodiments, the oral hygiene mouth spraycomposition may comprise water, xylitol, erythritol, inulin,methylsulfonylmethane, glycerin, sodium bicarbonate, vitamin C, xanthangum, and a flavoring agent. In some embodiments, the oral hygiene mouthspray composition may comprise water, xylitol, erythritol, inulin,methylsulfonylmethane, glycerin, sodium bicarbonate, vitamin C, xanthangum, sodium gluconate, flavoring agent, or a mixture thereof. In someembodiments, the oral hygiene mouth spray composition may comprisewater, xylitol, erythritol, inulin, methylsulfonylmethane, glycerin,sodium bicarbonate, vitamin C, xanthan gum, sodium gluconate, and aflavoring agent.

Devices

Devices comprising the oral hygiene composition are disclosed herein. Insome embodiments, a device may include a flossing material and an oralhygiene composition described herein.

In some embodiments, the flossing material may be selected frompolyester, rayon, viscose rayon, polytetrafluoroethylene (PTFE), nylon,Teflon, silk, and combinations thereof. In some embodiments, theflossing material has a thread count of, of about, of at least, or of atleast about 500 dtex, 700 dtex, 900 dtex, 950 dtex, 1000 dtex, 1050dtex, 1070 dtex, 1100 dtex, 1150 dtex, 1200 dtex, 1250 dtex, 1300 dtex,1350 dtex, 1370 dtex, 1400 dtex, 1500 dtex, 1700 dtex or 2000 dtex, orany range of values therebetween. In some embodiments, the flossingmaterial comprises the oral hygiene composition. In some embodiments,the oral hygiene composition is absorbed into the flossing material. Insome embodiments, the flossing material is configured to expand due tomechanical friction. Examples of flossing materials include Riser®Expanding Floss.

In some embodiments, the oral hygiene device may further comprisehydroxyapatite, xylitol, erythritol, stevia leaf extract, vitamin D3,vitamin K2, or a mixture thereof. In some embodiments, the oral hygienedevice may further comprise hydroxyapatite, xylitol, erythritol, stevialeaf extract, vitamin D3, and vitamin K2. In some embodiments, the oralhygiene device may further comprise hydroxyapatite, xylitol, erythritol,stevia leaf extract, vitamin D3, vitamin K2, limonene, linalool, or amixture thereof. In some embodiments, the oral hygiene device mayfurther comprise hydroxyapatite, xylitol, erythritol, stevia leafextract, vitamin D3, vitamin K2, limonene, and linalool. In someembodiments, the device further includes aroma. In some embodiments, thedevice further includes a wax. In some embodiments, the flossingmaterial further includes a wax. In some embodiments, the wax mayinclude beeswax.

In some embodiments, the oral hygiene device comprises limonene of, ofabout, of at least, or at least about, 0.01 wt. %, 0.02 wt. %, 0.03 wt.%, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt.%, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt. %, 0.6 wt. 0.7wt. %, 0.8 wt. %, 0.9 wt. %, 1 wt. %, 1.5 wt. %, 2 wt. %, 3 wt. %, 4 wt.% or 5 wt. %, or any range of values therebetween. For example, in someembodiments, the amount of limonene in the oral hygiene device is or isabout in any one of the following ranges: 0.01-0.1 wt. %, 0.1-1 wt. %,0.1-2 wt. %, 0.5-1.5 wt. %, 0.1-0.3 wt. % or 0.1-0.9 wt. % (based ontotal weight of the composition).

In some embodiments, the oral hygiene device comprises linalool of, ofabout, of at least, or at least about, 0.01 wt. %, 0.02 wt. %, 0.03 wt.%, 0.04 wt. %, 0.05 wt. %, 0.06 wt. %, 0.07 wt. %, 0.08 wt. %, 0.09 wt.%, 0.1 wt. %, 0.2 wt. %, 0.3 wt. %, 0.4 wt. %, 0.5 wt. %, 0.6 wt. 0.7wt. %, 0.8 wt. %, 0.9 wt. %, or 1 wt. %, or any range of valuestherebetween. For example, in some embodiments, the amount of linaloolin the oral hygiene device is or is about in any one of the followingranges: 0.01-0.09 wt. %, 0.1-1 wt. %, 0.01-1 wt. %, or 0.05-0.5 wt. %(based on total weight of the composition).

Methods of Treatment

The oral hygiene compositions and/or devices described here may beutilized to treat a subject. In some embodiments, the subject may be anadult and/or a child.

Some embodiments described herein generally relate to a method oftreating or preventing bone growth deficiencies within a mouth or noseof the subject, harmful bacterial growth within the oral cavity, gingivainflammation within the oral cavity, tooth decay within the oral cavity,tooth mineralization deficiencies, bone mineralization deficiencies, gumdisease and/or halitosis (e.g., bad breath). In some embodiments, theoral hygiene compositions and/or devices described here may be utilizedto promote beneficial bacterial growth within the oral cavity. In someembodiments, the oral hygiene compositions and/or devices described heremay be utilized to whiten teeth, alkalize the pH of the mouth, reducetooth and/or root sensitivity, and/or buffer teeth against acid erosion.

In some embodiments, the oral hygiene composition and/or device isadministered to the oral cavity of a subject. In some embodiments, theoral hygiene composition and/or device is administered to the tooth of asubject. In some embodiments, the oral hygiene composition and/or deviceis administered between adjacent teeth of a subject. In someembodiments, the oral hygiene composition and/or device is administeredto the gums of a subject.

Kits

Some embodiments described herein relate to a kit that can include anoral hygiene composition and/or device described herein. In someembodiments, the kit further comprises at least 1, 2, 3, 4 or fivecontainers.

In some embodiments, the kit may include a remineralization agent, ananti-inflammatory agent, a prebiotic agent, an alkalizing agent, or amixture thereof. For example, in some embodiments, the kit may include aremineralization agent, an anti-inflammatory agent, a prebiotic agent,and an alkalizing agent. In some embodiments, the kit may include aremineralization agent, an anti-inflammatory agent, and a prebioticagent. In some embodiments, the kit may include an anti-inflammatoryagent, a prebiotic agent, and an alkalizing agent. In some embodiments,the kit may include a remineralization agent and a prebiotic agent.

Examples

Varies oral hygiene compositions and devices have been prepare,utilizing the mixtures disclosed hereinabove. Some oral hygienecomposition embodiments include toothpastes, mouthwashes, mouth sprays,and dental flosses. Example formulations of oral hygiene compositionsare disclosed herein.

Example 1: Toothpaste Formulation

A toothpaste composition comprising:

-   -   19 wt. % water;    -   15 wt. % hydrated silica;    -   15 wt. % hydroxyapatite;    -   17 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   1 wt. % calcium carbonate;    -   0.3 wt. % quillaja saponaria extract;    -   0.05 wt. % stevia leaf extract;    -   0.5 wt. % dicalcium phosphate;    -   0.45 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   <4 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2; and    -   0.2 wt. % flavoring agent.

Example 2: Toothpaste Formulation

A toothpaste composition comprising:

-   -   balance water;    -   15 wt. % hydrated silica;    -   5 wt. % hydroxyapatite;    -   20.5 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   1 wt. % calcium carbonate;    -   0.3 wt. % quillaja saponaria extract;    -   0.08 wt. % stevia leaf extract;    -   0.5 wt. % dicalcium phosphate;    -   0.35 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2;    -   1 wt. % color; and    -   0.26 wt. % flavoring agent.

Example 3: Toothpaste Formulation

A toothpaste composition comprising:

-   -   20.8 wt. % water;    -   15 wt. % hydrated silica;    -   15 wt. % hydroxyapatite;    -   24 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   0.3 wt. % quillaja saponaria extract;    -   0.08 wt. % stevia leaf extract;    -   0.35 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2;    -   0.24 wt. % sodium fluoride;    -   0.8 wt. % color; and    -   0.26 wt. % flavoring agent.

Example 4: Toothpaste Formulation

A toothpaste composition comprising:

-   -   balance water;    -   15 wt. % hydrated silica;    -   15 wt. % hydroxyapatite;    -   24 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   0.3 wt. % quillaja saponaria extract;    -   0.08 wt. % stevia leaf extract;    -   0.35 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2;    -   1.1 wt. % sodium fluoride;    -   0.8 wt. % color; and    -   0.26 wt. % flavoring agent.

Example 5: Toothpaste Formulation

A toothpaste composition comprising:

-   -   balance water;    -   15 wt. % hydrated silica;    -   1-15 wt. % hydroxyapatite;    -   17 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   1 wt. % calcium carbonate;    -   0.3 wt. % quillaja saponaria extract;    -   0.05 wt. % stevia leaf extract;    -   0.5 wt. % dicalcium phosphate;    -   0.45 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   <4 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2; and    -   0.2 wt. % flavoring agent.

Example 6: Toothpaste Formulation

A toothpaste composition comprising:

-   -   balance water;    -   15 wt. % hydrated silica;    -   1-15 wt. % hydroxyapatite;    -   20.5 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   1 wt. % calcium carbonate;    -   0.3 wt. % quillaja saponaria extract;    -   0.08 wt. % stevia leaf extract;    -   0.5 wt. % dicalcium phosphate;    -   0.35 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2;    -   1 wt. % color; and    -   0.26 wt. % flavoring agent.

Example 7: Toothpaste Formulation

A toothpaste composition comprising:

-   -   balance water;    -   15 wt. % hydrated silica;    -   1-15 wt. % hydroxyapatite;    -   24 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   0.3 wt. % quillaja saponaria extract;    -   0.08 wt. % stevia leaf extract;    -   0.35 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2;    -   0.24 wt. % sodium fluoride;    -   0.8 wt. % color; and    -   0.26 wt. % flavoring agent.

Example 8: Toothpaste Formulation

A toothpaste composition comprising:

-   -   balance water;    -   15 wt. % hydrated silica;    -   1-15 wt. % hydroxyapatite;    -   24 wt. % glycerin;    -   10 wt. % erythritol;    -   15 wt. % xylitol;    -   5 wt. % inulin;    -   1 wt. % methylsulfonylmethane;    -   0.3 wt. % quillaja saponaria extract;    -   0.08 wt. % stevia leaf extract;    -   0.35 wt. % xanthan gum;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.05 wt. % cranberry seed oil;    -   0.0015 wt. % vitamin D3;    -   0.006 wt. % vitamin K2;    -   1.1 wt. % sodium fluoride;    -   0.8 wt. % color; and    -   0.26 wt. % flavoring agent.

Example 9: Mouthwash Formulation

A mouthwash composition comprising:

-   -   66 wt. % water;    -   10 wt. % xylitol;    -   10 wt. % erythritol;    -   5 wt. % inulin;    -   5 wt. % hydroxyapatite;    -   2 wt. % glycerin;    -   1 wt. % sodium bicarbonate;    -   1 wt. % methylsulfonylmethane;    -   0.1 wt. % vitamin C;    -   <4 wt. % sodium gluconate;    -   0.08 wt. % xanthan gum; and    -   0.2 wt. % flavoring agent.

Example 10: Mouthwash Formulation

A mouthwash composition comprising:

-   -   63.2 wt. % water;    -   10 wt. % xylitol;    -   10 wt. % erythritol;    -   5 wt. % inulin;    -   5 wt. % hydroxyapatite;    -   2 wt. % glycerin;    -   1 wt. % sodium bicarbonate;    -   1 wt. % methylsulfonylmethane;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.08 wt. % xanthan gum;    -   0.000025 wt. % vitamin D3;    -   0.0001 wt. % vitamin K2;    -   0.4 wt. % color; and    -   0.25 wt. % flavoring agent.

Example 11: Mouthwash Formulation

A mouthwash composition comprising:

-   -   63 wt. % water;    -   10 wt. % xylitol;    -   10 wt. % erythritol;    -   5 wt. % inulin;    -   5 wt. % hydroxyapatite;    -   2 wt. % glycerin;    -   1 wt. % sodium bicarbonate;    -   1 wt. % methylsulfonylmethane;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.08 wt. % xanthan gum;    -   0.02 wt. % sodium fluoride;    -   0.000025 wt. % vitamin D3;    -   0.0001 wt. % vitamin K2;    -   0.6 wt. % color; and    -   0.25 wt. % flavoring agent.

Example 12: Mouthwash Formulation

A mouthwash composition comprising:

-   -   balance water;    -   10 wt. % xylitol;    -   10 wt. % erythritol;    -   5 wt. % inulin;    -   5 wt. % hydroxyapatite;    -   2 wt. % glycerin;    -   1 wt. % sodium bicarbonate;    -   1 wt. % methylsulfonylmethane;    -   0.1 wt. % vitamin C;    -   2 wt. % sodium gluconate;    -   0.08 wt. % xanthan gum;    -   0.05 wt. % sodium fluoride;    -   0.000025 wt. % vitamin D3;    -   0.0001 wt. % vitamin K2;    -   0.6 wt. % color; and    -   0.25 wt. % flavoring agent.

Example 13: Mouth Spray Formulation

A mouth spray composition comprising:

-   -   68 wt. % water;    -   15 wt. % xylitol;    -   15 wt. % erythritol;    -   5 wt. % inulin;    -   0.5 wt. % methylsulfonylmethane;    -   2 wt. % glycerin;    -   1 wt. % sodium bicarbonate;    -   <4 wt. % sodium gluconate;    -   0.1 wt. % vitamin C;    -   0.08 wt. % xanthan gum; and    -   0.2 wt. % flavoring agent.

Example 14: Mouth Spray Formulation

A mouth spray composition comprising:

-   -   69.1 wt. % water;    -   10 wt. % xylitol;    -   10 wt. % erythritol;    -   5 wt. % inulin;    -   0.5 wt. % methylsulfonylmethane;    -   2 wt. % glycerin;    -   1 wt. % sodium bicarbonate;    -   2 wt. % sodium gluconate;    -   0.1 wt. % vitamin C;    -   0.08 wt. % xanthan gum; and    -   0.2 wt. % flavoring agent.

Example 15: Dental Floss Device

A dental floss material comprising:

-   -   Riser® Expanding Floss;    -   3 wt. % hydroxyapatite;    -   2 wt. % xylitol;    -   1.5 wt. % erythritol; and    -   1.5 wt. % stevia leaf extract.

Example 16: Dental Floss Device

A dental floss material comprising:

-   -   Riser® Expanding Floss;    -   1-5 wt. % hydroxyapatite;    -   0.1-5 wt. % fluoride;    -   0.1-5 wt. % xylitol;    -   0.1-5 wt. % erythritol; and    -   0.1-5 wt. % stevia leaf extract.

Example 17: Dental Floss Device

A dental floss material comprising:

-   -   Riser® Expanding Floss;    -   1-5 wt. % hydroxyapatite;    -   0.1-5 wt. % fluoride;    -   0.1-5 wt. % xylitol;    -   0.1-5 wt. % erythritol;    -   0.1-5 wt. % stevia leaf extract;    -   0.1-1 wt. % vitamin D3; and    -   0.1-1 wt. % vitamin K2.

Example 18: Dental Floss Device

A dental floss material comprising:

-   -   Floss material;    -   75-88.5 wt. % beeswax;    -   10-25 wt. % aroma (e.g. vanilla, strawberry and/or chocolate);    -   1-5 wt. % hydroxyapatite;    -   0.1-1 wt. % xylitol;    -   0.1-1 wt. % erythritol;    -   0.1-1 wt. % stevia leaf extract;    -   0.1-1 wt. % vitamin D3; and    -   0.1-1 wt. % vitamin K2.

Example 19: Dental Floss Device

A dental floss material comprising:

-   -   Floss material;    -   75-88.3 wt. % beeswax;    -   10-25 wt. % aroma;    -   1-5 wt. % hydroxyapatite;    -   0.1-1 wt. % xylitol;    -   0.1-1 wt. % erythritol;    -   0.11 wt. % stevia leaf extract;    -   0.1-1 wt. % vitamin D3;    -   0.1-1 wt. % vitamin K2    -   0.1-1 wt. % limonene; and    -   0.1-1 wt. % linalool.

While certain embodiments have been described, these embodiments havebeen presented by way of example only, and are not intended to limit thescope of the disclosure. Indeed, the novel methods and systems describedherein may be embodied in a variety of other forms. Furthermore, variousomissions, substitutions and changes in the systems and methodsdescribed herein may be made without departing from the spirit of thedisclosure. The accompanying claims and their equivalents are intendedto cover such forms or modifications as would fall within the scope andspirit of the disclosure.

Features, materials, characteristics, or groups described in conjunctionwith a particular aspect, embodiment, or example are to be understood tobe applicable to any other aspect, embodiment or example described inthis section or elsewhere in this specification unless incompatibletherewith. All of the features disclosed in this specification(including any accompanying claims, abstract and drawings), and/or allof the steps of any method or process so disclosed, may be combined inany combination, except combinations where at least some of suchfeatures and/or steps are mutually exclusive. The protection is notrestricted to the details of any foregoing embodiments. The protectionextends to any novel one, or any novel combination, of the featuresdisclosed in this specification (including any accompanying claims,abstract and drawings), or to any novel one, or any novel combination,of the steps of any method or process so disclosed.

Furthermore, certain features that are described in this disclosure inthe context of separate implementations can also be implemented incombination in a single implementation. Conversely, various featuresthat are described in the context of a single implementation can also beimplemented in multiple implementations separately or in any suitablesubcombination. Moreover, although features may be described above asacting in certain combinations, one or more features from a claimedcombination can, in some cases, be excised from the combination, and thecombination may be claimed as a subcombination or variation of asubcombination.

For purposes of this disclosure, certain aspects, advantages, and novelfeatures are described herein. Not necessarily all such advantages maybe achieved in accordance with any particular embodiment. Thus, forexample, those skilled in the art will recognize that the disclosure maybe embodied or carried out in a manner that achieves one advantage or agroup of advantages as taught herein without necessarily achieving otheradvantages as may be taught or suggested herein.

The scope of the present disclosure is not intended to be limited by thespecific disclosures of preferred embodiments in this section orelsewhere in this specification, and may be defined by claims aspresented in this section or elsewhere in this specification or aspresented in the future. The language of the claims is to be interpretedbroadly based on the language employed in the claims and not limited tothe examples described in the present specification or during theprosecution of the application, which examples are to be construed asnon-exclusive.

The headings provided herein, if any, are for convenience only and donot necessarily affect the scope or meaning of the devices and methodsdisclosed herein.

1. An oral hygiene composition, comprising at least the followingingredients: a remineralization agent; an anti-inflammatory agent; aprebiotic agent; and an alkalizing agent.
 2. The composition of claim 1,wherein the remineralization agent comprises a compound selected fromthe group consisting of hydroxyapatite, vitamin D3, vitamin K2, calciumcarbonate, dicalcium phosphate, fluoride, and combinations thereof. 3.The composition of claim 1, wherein the remineralization agent compriseshydroxyapatite, vitamin D3 and vitamin K2.
 4. The composition of claim1, wherein the oral hygiene composition comprises: 1-20 wt. %hydroxyapatite; 0.00001-0.01 wt. % vitamin D3; and 0.00001-0.012 wt. %vitamin K2.
 5. The composition of claim 3, further comprising fluoride.6. The composition of claim 5, wherein the oral hygiene compositioncomprises 0.01-1.5 wt. % fluoride.
 7. The composition of claim 1,wherein the anti-inflammatory agent comprises a compound or compositionselected from the group consisting of methylsulfonylmethane, vitamin C,cranberry seed oil, sodium gluconate, and combinations thereof.
 8. Thecomposition of claim 1, wherein the anti-inflammatory agent comprisesmethylsulfonylmethane, vitamin C and cranberry seed oil.
 9. Thecomposition of claim 1, wherein the oral hygiene composition comprises:0.5-3 wt. % methylsulfonylmethane; 0.05-0.2 wt. % vitamin C; and0.02-0.1 wt. % cranberry seed oil.
 10. The composition of claim 1,wherein the prebiotic agent comprises a compound or composition selectedfrom the group consisting of inulin, xylitol, erythritol, cranberry seedoil, xanthan gum, stevia leaf extract, and combinations thereof. 11.(canceled)
 12. The composition of claim 1, wherein the oral hygienecomposition comprises: 3-7 wt. % inulin; 5-20 wt. % xylitol; and 5-10wt. % erythritol.
 13. (canceled)
 14. The composition of claim 1, whereinthe alkalizing agent comprises a compound selected from the groupconsisting of sodium bicarbonate, xylitol, erythritol, and combinationsthereof.
 15. (canceled)
 16. The composition of claim 1, wherein the oralhygiene composition comprises: 0.5-3.0 wt. % sodium bicarbonate; 5-20wt. % xylitol; and 5-10 wt. % erythritol.
 17. The composition of claim1, wherein the composition further comprises a solvent.
 18. Thecomposition of claim 17, wherein the solvent comprises a compoundselected from the group consisting of water, glycerin, and combinationsthereof.
 19. (canceled)
 20. The composition of claim 17, wherein theoral hygiene composition comprises: 15-75 wt. % water; and 1-20 wt. %glycerin.
 21. The composition of claim 1, wherein composition furthercomprises a cleaning agent.
 22. The composition of claim 21, wherein thecleaning agent comprises a compound or composition selected from thegroup consisting of hydrated silica, quillaja saponaria extract, andcombinations thereof.
 23. (canceled)
 24. The composition of claim 21,wherein the oral hygiene composition comprises: 10-20 wt. % hydratedsilica; and 0.1-2 wt. % quillaja saponaria extract.
 25. (canceled) 26.(canceled)
 27. (canceled)
 28. (canceled)
 29. (canceled)
 30. (canceled)31. (canceled)
 32. A dental floss device comprising a flossing materialand wherein the flossing material comprises: a remineralization agent;and a prebiotic agent.
 33. The dental floss device of claim 32, whereinthe remineralization agent comprises a compound selected from the groupconsisting of hydroxyapatite, vitamin D3, vitamin K2, fluoride, calciumcarbonate, dicalcium phosphate, and combinations thereof.
 34. The dentalfloss device of claim 32, wherein the remineralization agent compriseshydroxyapatite.
 35. The dental floss device of claim 33 or 31, whereinthe flossing material comprises 1-15 wt. % of hydroxyapatite.
 36. Thedental floss device of claim 32, further comprising vitamin D3 andvitamin K2.
 37. The dental floss device of claim 36, wherein theflossing material comprises 0.1-1 wt. % of vitamin D3 and 0.1-1 wt. % ofvitamin K2.
 38. The dental floss device of claim 32, further comprisingfluoride.
 39. The dental floss device of claim 38, wherein the flossingmaterial comprises 0.1-5 wt. % of fluoride.
 40. The dental floss deviceof claim 32, wherein the prebiotic agent comprises a compound orcomposition selected from the group consisting of inulin, xylitol,erythritol, cranberry seed oil, xanthan gum, stevia leaf extract, andcombinations thereof.
 41. (canceled)
 42. The dental floss device ofclaim 32, wherein the flossing material comprises: 1-15 wt. % ofxylitol; 1-15 wt. % of erythritol; and 1-15 wt. % of stevia leafextract.
 43. (canceled)
 44. The dental floss device of claim 32, whereinthe flossing material further comprises a wax.
 45. (canceled) 46.(canceled)
 47. (canceled)
 48. (canceled)
 49. (canceled)
 50. (canceled)51. (canceled)
 52. (canceled)
 53. (canceled)
 54. (canceled) 55.(canceled)
 56. (canceled)
 57. (canceled)
 58. (canceled)
 59. (canceled)